2004
PREDICTIVE PARAMETERS OF THE WALDEYERS RING CARCINOMAS (A RETROSPECTIVE STUDY)
SMILEK, Pavel, Rom KOSTŘICA, Jan ROTTENBERG, Karel VESELÝ, Ladislav DUŠEK et. al.Základní údaje
Originální název
PREDICTIVE PARAMETERS OF THE WALDEYERS RING CARCINOMAS (A RETROSPECTIVE STUDY)
Název anglicky
PREDICTIVE PARAMETERS OF THE WALDEYERS RING CARCINOMAS (A RETROSPECTIVE STUDY)
Autoři
SMILEK, Pavel (203 Česká republika, garant), Rom KOSTŘICA (203 Česká republika), Jan ROTTENBERG (203 Česká republika), Karel VESELÝ (203 Česká republika) a Ladislav DUŠEK (203 Česká republika)
Vydání
Athény, Řecko, 5th European congress of Oto-Rhino-Laryngology head and Neck Surgery Abstract Book, s. 234-234, 2004
Nakladatel
C and C International S.A.
Další údaje
Jazyk
čeština
Typ výsledku
Stať ve sborníku
Obor
30200 3.2 Clinical medicine
Stát vydavatele
Česká republika
Utajení
není předmětem státního či obchodního tajemství
Kód RIV
RIV/00216224:14110/04:00010301
Organizační jednotka
Lékařská fakulta
Klíčová slova anglicky
head and neck cancer; predictiv parameters
Změněno: 20. 9. 2004 11:49, doc. MUDr. Pavel Smilek, Ph.D.
V originále
The analysis was carried out with a set of 60 patients suffering from carcinoma of the pharynx and supraglottis. Besides routine examinations, flow cytometric analysis of was performed, p53 and Ki-67 markers were established by means of immunohistochemistry. Furthermore mitotic and apoptotic index were established. Event-free survival (EFS) and overall survival (OS) were accepted as primary endpoints for the prognostic analyses. Cytokinetic parameters and proliferation activity were found as important predictors of the second level (after recognizing stage, grade and DNA status of the tumor). Multivariate combination of these markers contributed namely to the prognosis of early risk event (i.e. progression or relapse of the disease up to 12 months after the end of the therapy): ratio SPF/G2M cell fractions was found to be the key prognostic factor (p < 0.01). Early progressed cases have typically decreased SPF fraction combined with increased mitotic activity.
Anglicky
The analysis was carried out with a set of 60 patients suffering from carcinoma of the pharynx and supraglottis. Besides routine examinations, flow cytometric analysis of was performed, p53 and Ki-67 markers were established by means of immunohistochemistry. Furthermore mitotic and apoptotic index were established. Event-free survival (EFS) and overall survival (OS) were accepted as primary endpoints for the prognostic analyses. Cytokinetic parameters and proliferation activity were found as important predictors of the second level (after recognizing stage, grade and DNA status of the tumor). Multivariate combination of these markers contributed namely to the prognosis of early risk event (i.e. progression or relapse of the disease up to 12 months after the end of the therapy): ratio SPF/G2M cell fractions was found to be the key prognostic factor (p < 0.01). Early progressed cases have typically decreased SPF fraction combined with increased mitotic activity.
Návaznosti
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