Detailed Information on Publication Record
2004
PREDICTIVE PARAMETERS OF THE WALDEYERS RING CARCINOMAS (A RETROSPECTIVE STUDY)
SMILEK, Pavel, Rom KOSTŘICA, Jan ROTTENBERG, Karel VESELÝ, Ladislav DUŠEK et. al.Basic information
Original name
PREDICTIVE PARAMETERS OF THE WALDEYERS RING CARCINOMAS (A RETROSPECTIVE STUDY)
Name (in English)
PREDICTIVE PARAMETERS OF THE WALDEYERS RING CARCINOMAS (A RETROSPECTIVE STUDY)
Authors
SMILEK, Pavel (203 Czech Republic, guarantor), Rom KOSTŘICA (203 Czech Republic), Jan ROTTENBERG (203 Czech Republic), Karel VESELÝ (203 Czech Republic) and Ladislav DUŠEK (203 Czech Republic)
Edition
Athény, Řecko, 5th European congress of Oto-Rhino-Laryngology head and Neck Surgery Abstract Book, p. 234-234, 2004
Publisher
C and C International S.A.
Other information
Language
Czech
Type of outcome
Stať ve sborníku
Field of Study
30200 3.2 Clinical medicine
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
RIV identification code
RIV/00216224:14110/04:00010301
Organization unit
Faculty of Medicine
Keywords in English
head and neck cancer; predictiv parameters
Změněno: 20/9/2004 11:49, doc. MUDr. Pavel Smilek, Ph.D.
V originále
The analysis was carried out with a set of 60 patients suffering from carcinoma of the pharynx and supraglottis. Besides routine examinations, flow cytometric analysis of was performed, p53 and Ki-67 markers were established by means of immunohistochemistry. Furthermore mitotic and apoptotic index were established. Event-free survival (EFS) and overall survival (OS) were accepted as primary endpoints for the prognostic analyses. Cytokinetic parameters and proliferation activity were found as important predictors of the second level (after recognizing stage, grade and DNA status of the tumor). Multivariate combination of these markers contributed namely to the prognosis of early risk event (i.e. progression or relapse of the disease up to 12 months after the end of the therapy): ratio SPF/G2M cell fractions was found to be the key prognostic factor (p < 0.01). Early progressed cases have typically decreased SPF fraction combined with increased mitotic activity.
In English
The analysis was carried out with a set of 60 patients suffering from carcinoma of the pharynx and supraglottis. Besides routine examinations, flow cytometric analysis of was performed, p53 and Ki-67 markers were established by means of immunohistochemistry. Furthermore mitotic and apoptotic index were established. Event-free survival (EFS) and overall survival (OS) were accepted as primary endpoints for the prognostic analyses. Cytokinetic parameters and proliferation activity were found as important predictors of the second level (after recognizing stage, grade and DNA status of the tumor). Multivariate combination of these markers contributed namely to the prognosis of early risk event (i.e. progression or relapse of the disease up to 12 months after the end of the therapy): ratio SPF/G2M cell fractions was found to be the key prognostic factor (p < 0.01). Early progressed cases have typically decreased SPF fraction combined with increased mitotic activity.
Links
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