LANDA, Leoš, Karel ŠLAIS and Alexandra ŠULCOVÁ. The influence of felbamate on sensitization to methamphetamine behavioural effects in mice. European Neuropsychopharmacology. Amsterdam: Elsevier, 2004, vol. 14, Suppl. 3, p. S346-S346, 2 pp. ISSN 0924-977X.
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Basic information
Original name The influence of felbamate on sensitization to methamphetamine behavioural effects in mice.
Name in Czech Vliv felbamátu na rozvoj sensitizace k behaviorálním účinkům metamfetqaminu u myší
Authors LANDA, Leoš (203 Czech Republic, guarantor), Karel ŠLAIS (203 Czech Republic) and Alexandra ŠULCOVÁ (203 Czech Republic).
Edition European Neuropsychopharmacology, Amsterdam, Elsevier, 2004, 0924-977X.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30104 Pharmacology and pharmacy
Country of publisher Netherlands
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 3.545
RIV identification code RIV/00216224:14110/04:00010402
Organization unit Faculty of Medicine
UT WoS 000225460400480
Keywords in English behavioural sensitization; methamphetamine; felbamate; mice
Tags behavioural sensitization, felbamate, methamphetamine, mice
Changed by Changed by: prof. MUDr. Alexandra Šulcová, CSc., učo 1937. Changed: 16/5/2005 11:26.
Abstract
Numerous studies refer to the important involvement of N-methyl-D-aspartate (NMDA) receptors in the development and expression of behavioural sensitization. Activating antiepileptic drugs of the 3rd generation, such as felbamate (FEL) also invoke psychotropic effects. They may possess attention-enhancing and antidepressant efficacy, cause anxiety, insomnia, and agitation. All pharmacological mechanisms of felbamate are not fully elucidated yet, but many of clinical effects may be related to the inhibition of NMDA currents. The present study focuses on investigation of felbamate influence on sensitization to methamphetamine effects on mouse locomotor/exploratory behaviour in the open field.We desribed prevention of expression of metamphetamine sensitization effect in the mice which received the drug challenge dose combined with felbamate.
Abstract (in Czech)
Výsledky potvrdily preventivní efekt felbamátu k expresi sensitizace k behaviorálním účinkům dávky metafetaminu po dané po vysazení opakového podávání této drogy.
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