VĚTVIČKA, Václav, Jana VĚTVIČKOVÁ and Petr BENEŠ. Role of enzymatically inactive procathepsin D in lung cancer. Anticancer Research. Řecko: INT INST ANTICANCER RESEARCH, 2004, vol. 24, No 5, p. 2739-2743. ISSN 0250-7005.
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Basic information
Original name Role of enzymatically inactive procathepsin D in lung cancer.
Name in Czech Úloha enzymaticky inaktivního prokatepsinu D v rakovině plic.
Authors VĚTVIČKA, Václav (203 Czech Republic), Jana VĚTVIČKOVÁ (203 Czech Republic) and Petr BENEŠ (203 Czech Republic, guarantor).
Edition Anticancer Research, Řecko, INT INST ANTICANCER RESEARCH, 2004, 0250-7005.
Other information
Original language English
Type of outcome Article in a journal
Field of Study Genetics and molecular biology
Country of publisher Greece
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 1.395
Organization unit Faculty of Science
UT WoS 000224629700020
Keywords in English procathepsin D; proliferation; lung cancer; invasiveness
Tags invasiveness, lung cancer, procathepsin D, proliferation
Tags International impact, Reviewed
Changed by Changed by: doc. Mgr. Petr Beneš, Ph.D., učo 2082. Changed: 2/10/2008 14:14.
Abstract
Procathepsin D is over-secreted by some human cancer cells. This enzymatically inactive precursor has been established as playing an important role in the development of several types of cancer. In the present investigation, we used both the isolated human procathepsin D and a synthetic 44 amino acid peptide corresponding to the activation peptide of procathepsin D to test their effects on the proliferation of lung cancer cells. We showed that both the procathepsin D and the activation peptide act as growth factors. In parallel, we also measured the secretion of procathepsin D by lung cancer cells and compared the secretion with invasiveness through Matrigel membrane. Our findings represent the first experimental data showing the direct effects of procathepsin D and its activation peptide on growth and invasiveness of lung cancer cells.
Abstract (in Czech)
V této práci jsme prokázali vliv prokatepsinu D a jeho aktivačního peptidu na růst a invazivitu linií karcinomu plic.
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