PISTOVČÁKOVÁ, Jana, Miroslav DOSTÁLEK, Jan JUŘICA, Josef TOMANDL, Ivan LINHART, Alexandra ŠULCOVÁ a Eva HADAŠOVÁ. Effect of St. Johns wort (Hypericum perforatum) standardized extract on leukocyte phagocytosis in rat model of depression. Psychiatrie. Praha: Tigis, s.r.o., 2004, roč. 8, Suppl.4, s. 39-40. ISSN 1211-7579. |
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@article{561266, author = {Pistovčáková, Jana and Dostálek, Miroslav and Juřica, Jan and Tomandl, Josef and Linhart, Ivan and Šulcová, Alexandra and Hadašová, Eva}, article_location = {Praha}, article_number = {Suppl.4}, keywords = {depression; Hypericum perforatum; LI160; rat; olfactory bulbectomy; immunity; leukocyte phagocytosis}, language = {eng}, issn = {1211-7579}, journal = {Psychiatrie}, title = {Effect of St. Johns wort (Hypericum perforatum) standardized extract on leukocyte phagocytosis in rat model of depression}, volume = {8}, year = {2004} }
TY - JOUR ID - 561266 AU - Pistovčáková, Jana - Dostálek, Miroslav - Juřica, Jan - Tomandl, Josef - Linhart, Ivan - Šulcová, Alexandra - Hadašová, Eva PY - 2004 TI - Effect of St. Johns wort (Hypericum perforatum) standardized extract on leukocyte phagocytosis in rat model of depression JF - Psychiatrie VL - 8 IS - Suppl.4 SP - 39-40 EP - 39-40 PB - Tigis, s.r.o. SN - 12117579 KW - depression KW - Hypericum perforatum KW - LI160 KW - rat KW - olfactory bulbectomy KW - immunity KW - leukocyte phagocytosis N2 - The effects of St. Johns wort (standardized herbal extract LI 160) on leukocyte phagocytic activity in the rodent model of depression, the olfactory bulbectomized (OB) rat were studied. The activity of leukocyte zymosan-induced phagocytosis was examined via measurement of chemiluminiscence potentiated by luminol. The results confirm an antidepressant-like behavioural impact of LI 160 (100 mg/kg/day, 10 days i.p.) in the OB rat model of depression. In the OB rats there was a signifficant suppression of the leukocyte phagocytic activity in comparison with the sham rats, which was disinhibited (p<0.05) by LI 160 (100 mg/kg/day, 10 days i.p.). However the dose used was generally immunostimulatory active as the increase in leukocyte phagocytosis (p<0.001) was found also in the control group of rats. This immunostimulant effect of the St. Johns wort standardized extract LI 160 might be important in clinics and deserves further investigation. ER -
PISTOVČÁKOVÁ, Jana, Miroslav DOSTÁLEK, Jan JUŘICA, Josef TOMANDL, Ivan LINHART, Alexandra ŠULCOVÁ a Eva HADAŠOVÁ. Effect of St. Johns wort (Hypericum perforatum) standardized extract on leukocyte phagocytosis in rat model of depression. \textit{Psychiatrie}. Praha: Tigis, s.r.o., 2004, roč.~8, Suppl.4, s.~39-40. ISSN~1211-7579.
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