2004
End-to-side anastomosis of peripheral nerve in experimental and clinical model
HANINEC, Pavel, Petr DUBOVÝ, Filip ŠÁMAL, Ladislav HOUŠŤAVA, Lubor STEJSKAL et. al.Základní údaje
Originální název
End-to-side anastomosis of peripheral nerve in experimental and clinical model
Název česky
End-to-side anastomosa periferního nervu v experimenálním a klinickém modelu
Autoři
HANINEC, Pavel (203 Česká republika), Petr DUBOVÝ (203 Česká republika, garant), Filip ŠÁMAL (203 Česká republika), Ladislav HOUŠŤAVA (203 Česká republika) a Lubor STEJSKAL (203 Česká republika)
Vydání
Amsterdam, DEVELOPMENTS IN NEUROSCIENCES, s. 471-477, 2004
Nakladatel
Elsevier
Další údaje
Jazyk
angličtina
Typ výsledku
Stať ve sborníku
Obor
30000 3. Medical and Health Sciences
Stát vydavatele
Nizozemské království
Utajení
není předmětem státního či obchodního tajemství
Kód RIV
RIV/00216224:14110/04:00010574
Organizační jednotka
Lékařská fakulta
ISBN
0-444-51488-0
ISSN
UT WoS
000221378100072
Klíčová slova anglicky
brachial plexus; reconstruction; end-to-side anastomosis; peripheral nerves
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 26. 6. 2009 10:42, prof. RNDr. Petr Dubový, CSc.
V originále
The results of 13 patients with end-to-side anastomosis of the axillary nerve to various donor nerves were presented. The results were evaluated by means of functional and electrophysiological methods following avulsion and subsequent reconstruction of the brachial plexus. End-to-side anastomosis of the rat musculocutaneus nerve (n=12) with the ulnar one was used in the experimental model. The retrograde tracers were applied to prove the reinnervation. Fair and good results were achieved in neurotization of the axillary nerve in 75% of patients with follow up longer than 24 months. Electrophysiology proved reinnervation in 100% of the patients. The average muscle strength, according to the muscle test, was 3.80. The functional recovery started within 7-12 months postoperatively. Retrograde staining in the experimental model demonstrated the reinnervation of the rat biceps muscles 3 months from end-to-side anastomosis, mainly by collateral reinnervation from the ulnar nerve. The ulnar nerve motoneurons (70ą13) were able to send off collateral sprouts from their intact axons into the musculocutaneus nerve. Other motoneurons of the same pool (21ą4) regenerated axons directly into the musculocutaneus nerve without collateral sprouting, probably due to the axonotmesis of the motor fibers during the preparation of perineurial window. Our results demonstrated that end-to-side anastomosis of the peripheral nerve might be successfully used for reinnervation procedures of brachial plexus injury, mainly in the cases with insufficient sources of motor nerve fibers from neighboring intact motor nerves.
Česky
Byly prezentovány výsledky 13 pacientů, u kterých byl poškozený n. axillaris spojen end-to-side anastomosou s různými donorovými nervy.
Návaznosti
| NF6658, projekt VaV |
|