BARTOŠOVÁ, L., Marek FRYDRYCH, G. HULÁKOVÁ, K. BERÁNKOVÁ, V. STRNADOVÁ, P. MOKRÝ, V. BRUNCLÍK, J. KOLEVSKÁ a Markéta BÉBAROVÁ. Efficacy of newly synthesized 44Bu ultrashort-acting beta-adrenergic antagonist to isoprenaline-induced tachycardia - comparison with esmolol. Acta Veterinaria Brunensis. Brno, 2004, roč. 73, č. 2, s. 171-179. ISSN 0001-7213. |
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@article{564250, author = {Bartošová, L. and Frydrych, Marek and Huláková, G. and Beránková, K. and Strnadová, V. and Mokrý, P. and Brunclík, V. and Kolevská, J. and Bébarová, Markéta}, article_location = {Brno}, article_number = {2}, keywords = {beta-blocker; isoprenaline; tachycardia; esmolol; ionic currents; rat}, language = {eng}, issn = {0001-7213}, journal = {Acta Veterinaria Brunensis}, title = {Efficacy of newly synthesized 44Bu ultrashort-acting beta-adrenergic antagonist to isoprenaline-induced tachycardia - comparison with esmolol}, volume = {73}, year = {2004} }
TY - JOUR ID - 564250 AU - Bartošová, L. - Frydrych, Marek - Huláková, G. - Beránková, K. - Strnadová, V. - Mokrý, P. - Brunclík, V. - Kolevská, J. - Bébarová, Markéta PY - 2004 TI - Efficacy of newly synthesized 44Bu ultrashort-acting beta-adrenergic antagonist to isoprenaline-induced tachycardia - comparison with esmolol JF - Acta Veterinaria Brunensis VL - 73 IS - 2 SP - 171-179 EP - 171-179 SN - 00017213 KW - beta-blocker KW - isoprenaline KW - tachycardia KW - esmolol KW - ionic currents KW - rat N2 - The aim of this study was testing of the action of three newly synthesized potential ultrashort acting beta-blockers on heart rate in rat. Bradycardic effect of the compound 44Bu was compared with the action of esmolol. The effects of 44Bu and esmolol were not different in the onset, but in the depth of heart rate decrease, above all at higher concentrations. We conclude that the ultrashort beta adrenergic blocking properties of 44Bu were verified. ER -
BARTOŠOVÁ, L., Marek FRYDRYCH, G. HULÁKOVÁ, K. BERÁNKOVÁ, V. STRNADOVÁ, P. MOKRÝ, V. BRUNCLÍK, J. KOLEVSKÁ a Markéta BÉBAROVÁ. Efficacy of newly synthesized 44Bu ultrashort-acting beta-adrenergic antagonist to isoprenaline-induced tachycardia - comparison with esmolol. \textit{Acta Veterinaria Brunensis}. Brno, 2004, roč.~73, č.~2, s.~171-179. ISSN~0001-7213.
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