MATĚJKOVÁ, Petra, David ŠMAJS, S.J. NORRIS and G.M. WEINSTOCK. Genome differences and detection of pathogenic Treponema pallidum subspecies. Clin. Microbiol. Infec., 2004, vol. 10, No 3, p. 451-452. ISSN 1198-743X.
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Basic information
Original name Genome differences and detection of pathogenic Treponema pallidum subspecies
Name in Czech Rozdíly v genomech patogenních poddruhů Treponema pallidum
Authors MATĚJKOVÁ, Petra (203 Czech Republic), David ŠMAJS (203 Czech Republic, guarantor), S.J. NORRIS (840 United States of America) and G.M. WEINSTOCK (724 Spain).
Edition Clin. Microbiol. Infec. 2004, 1198-743X.
Other information
Original language English
Type of outcome article in a journal
Field of Study Genetics and molecular biology
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 2.361
RIV identification code RIV/00216224:14110/04:00011950
Organization unit Faculty of Medicine
Keywords in English comparative genomics; Treponema pallidum
Tags comparative genomics, Treponema pallidum
Changed by Changed by: prof. MUDr. David Šmajs, Ph.D., učo 1116. Changed: 30/5/2005 13:11.
No extensive differences in genome structure between pallidum and pertenue subspecies including deletions and multiplications of genes using DNA microarray technology have been found. Sequencing showed no deletions and insertions of nucleotides (no ORF shifts). One can predict, that pallidum and pertenue genomes differ in one nucleotide per every 1640 bps (altogether in 700 nts).
Abstract (in Czech)
Byly zjišťovány rozdíly v genomech patogenních poddruhů Treponema pallidum. Genomy Treponema pallidum ssp. pallidum a pertenue se liší jedním nukleotidem na 1640 párů bází (celkem asi 700 nts párů bází ).
GA310/04/0021, research and development projectName: Postgenomické studie syfilitické spirochety Treponema pallidum
Investor: Czech Science Foundation, Standard Projects
NI7351, research and development projectName: Komparativní genomika patogenních spirochet rodu Treponema: cesta k sekvenčně specifické diagnostice
Investor: Ministry of Health of the CR, Infectious Diseases, Microbiology, Epidemiology and Immunology
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