| ŠLAIS, Karel, Nikola Jane BRIDGES a Eva SYKOVÁ. The effects of chronic corticosterone treatment on hippocampal astrocyte numbers in male and female rats. Psychiatrie. Praha: Tigis s.r.o., 2005, roč. 9, Suppl. 1, s. 52-52. ISSN 1211-7579. |
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@article{565508,
author = {Šlais, Karel and Bridges, Nikola Jane and Syková, Eva},
article_location = {Praha},
article_number = {Suppl. 1},
keywords = {corticosterone; astrocyte; rat; chronic stress},
language = {eng},
issn = {1211-7579},
journal = {Psychiatrie},
title = {The effects of chronic corticosterone treatment on hippocampal astrocyte numbers in male and female rats},
volume = {9},
year = {2005}
}
TY - JOUR
ID - 565508
AU - Šlais, Karel - Bridges, Nikola Jane - Syková, Eva
PY - 2005
TI - The effects of chronic corticosterone treatment on hippocampal astrocyte numbers in male and female rats
JF - Psychiatrie
VL - 9
IS - Suppl. 1
SP - 52-52
EP - 52-52
PB - Tigis s.r.o.
SN - 12117579
KW - corticosterone
KW - astrocyte
KW - rat
KW - chronic stress
N2 - The hippocampus is widely reported to be involved in the response to stress. High glucocorticoid serum levels have been associated with depression, post-traumatic stress disorder, and some aspects of cognitive dysfunction in humans. Much of the research conducted has focused primarily on the use of male animals, with little investigation of possible sex differences. The aim of the present study was to assess whether chronic (21 days) corticosterone treatment produces changes in hippocampal astrocyte numbers in male and female rats.Corticosterone treatment produced a dose-dependent increase in the number of astrocytes in the CA1 region when compared to both controls and placebo-treated animals. No difference was found between control and placebo animals, suggesting that pellet implantation itself had no effect and that all astrocyte alterations were a result of corticosterone application. The effect of both doses of corticosterone did not differ between males and females.
ER -
ŠLAIS, Karel, Nikola Jane BRIDGES a Eva SYKOVÁ. The effects of chronic corticosterone treatment on hippocampal astrocyte numbers in male and female rats. \textit{Psychiatrie}. Praha: Tigis s.r.o., 2005, roč.~9, Suppl. 1, s.~52-52. ISSN~1211-7579.
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