Detailed Information on Publication Record
2005
Prognostic significance of mitotic and apoptotic index and the DNA cytometry in head and neck cancer
SMILEK, Pavel, Ladislav DUŠEK, Karel VESELÝ, Jan ROTTENBERG, Rom KOSTŘICA et. al.Basic information
Original name
Prognostic significance of mitotic and apoptotic index and the DNA cytometry in head and neck cancer
Name in Czech
PrognostickĂ vĂznam mitotickĂŠho a apoptotickĂŠho indexu a DNA cytometrie u karcinom hlavy a krku
Authors
SMILEK, Pavel (203 Czech Republic, guarantor), Ladislav DUŠEK (203 Czech Republic), Karel VESELÝ (203 Czech Republic), Jan ROTTENBERG (203 Czech Republic) and Rom KOSTŘICA (203 Czech Republic)
Edition
Neoplasma, Bratislava, 2005, 0028-2685
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30200 3.2 Clinical medicine
Country of publisher
Croatia
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 0.731
RIV identification code
RIV/00216224:14110/05:00013722
Organization unit
Faculty of Medicine
UT WoS
000229259000003
Keywords in English
Head & neck cancer risk prognosis mitotic/apoptotic index DNA cytometry
Změněno: 7/7/2009 13:16, doc. MUDr. Pavel Smilek, Ph.D.
V originále
This study was conducted to analyze prognostic significance of mitotic and apoptotic index and the DNA flow cytometric analysis of HNSCC to the recurrence-free survival time and to the overall survival. The analysis was carried out with a set of 56 patients suffering from carcinoma of the pharynx and supraglottis. Cytokinetic parameters and proliferation activity were found as important predictors of the second level (after recognizing stage, grade and DNA status of the tumor). Multivariate combination of these markers contributed namely to the prognosis of early risk event: a ratio S phase cell fraction /G2M cell fraction was found to be the key prognostic factor (p < 0.01). Early risk events are associated with increased mitotic activity, decreased apoptic rate, decreased S phase cell fraction and significantly increased G2/M fraction.
In Czech
CĂlem prĂĄce je analĂza prognostickĂŠ hodnoty mitotickĂŠho a apoptotickĂŠho indexu a DNA flow-cytometrickĂĄ analĂza karcinom hlavy a krku ve vztahu k celkovĂŠmu pežitĂ a intervalu bez pĂznak choroby. Bylo hodnoceno 56 pacient s karcinomem faryngu a supraglottis. CytokinetickĂŠ parametry a proliferanĂ aktivita byly zhodnoceny jako dležitĂŠ prediktory druhĂŠ ady (po stanovenĂ TNM klasifikace, histopatol. Gradingu a DNA stavu nĂĄdoru). MultivarianĂ kombinace tchto marker pispla zejmĂŠna k prognĂłze asnĂch recidiv (p < 0.01). Riziko asnĂŠ recidivy souvisĂ se zvĂšenou mitotickou aktivitou, snĂženou apoptĂłzou, snĂženou S-fĂĄzĂ a signifikantn zvĂšenou G2/M frakcĂ bunnĂŠho cyklu.
Links
| MSM 141100003, plan (intention) |
|