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@article{571034,
author = {Bednařík, Josef and Vondráček, Petr and Dušek, Ladislav and Moravcová, Eva and Čundrle, Ivan},
article_location = {Darmstadt},
article_number = {3},
keywords = {sepsis; polyneuropathies; myopathies; critical illness; risk factors},
language = {eng},
issn = {0340-5354},
journal = {Journal of Neurology},
title = {Risk factors for critical illness polyneuromyopathy},
volume = {252},
year = {2005}
}
TY - JOUR
ID - 571034
AU - Bednařík, Josef - Vondráček, Petr - Dušek, Ladislav - Moravcová, Eva - Čundrle, Ivan
PY - 2005
TI - Risk factors for critical illness polyneuromyopathy
JF - Journal of Neurology
VL - 252
IS - 3
SP - 343-351
EP - 343-351
PB - Steinkopff Verlag
SN - 03405354
KW - sepsis
KW - polyneuropathies
KW - myopathies
KW - critical illness
KW - risk factors
N2 - Although numerous clinical, laboratory, and pharmacological variables have been reported as significant risk factors for critical illness polyneuromyopathy (CIPM), there is still no consensus on the aetiology of this condition. Objectives of the study was to assess the clinical and electrophysiological incidence and risk factors for CIPM. A cohort of critically ill patients was observed prospectively for a one-month period and the association between neuromuscular involvement and various potential risk factors was evaluated. Sixty one critically ill patients completed the follow-up (30 women, 31 men, median age 59 years). CIPM development was detected clinically in 17 patients (27.9%) and electrophysi-ologically in 35 patients (57.4%). CIPM was significantly associated with the pres-ence and duration of systemic inflammatory response syndrome and the severity of multiple, respiratory, central nervous, and cardiovascular organ failures. The median duration of mechanical ventilation was significantly longer in patients with CIPM com-pared with those without (16 vs 3 days, p< 0.001). Independent predictors of CIPM obtainable within the 1st week of critical illness were the admission sequential organ failure assessment score (odds ratio [OR], 1.15; 95% confidence interval [CI], 1.02-1.36) , the 1st week total sequential organ failure assessment scores (OR, 1.14; 95% CI, 1.06-1.46) and the 1st week duration of systemic inflammatory response syn-drome (OR, 1.05; 95% CI, 1.01-1.15). They were able to correctly predict the devel-opment of CIPM at the end of the 1st week in about 80% of critically ill cases. In conclusion, the presence and duration of systemic inflammatory response syn-drome and the severity of multiple and several organ failures are associated with in-creased risk of the development of CIPM.
ER -
BEDNAŘÍK, Josef, Petr VONDRÁČEK, Ladislav DUŠEK, Eva MORAVCOVÁ and Ivan ČUNDRLE. Risk factors for critical illness polyneuromyopathy. \textit{Journal of Neurology}. Darmstadt: Steinkopff Verlag, 2005, vol.~252, No~3, p.~343-351. ISSN~0340-5354.
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