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@article{571749, author = {Matějková, Petra and Šmajs, David and Norris, SJ and Weinstock, GM}, article_location = {Praha}, article_number = {97}, keywords = {comparative genomics; Treponema pallidum}, language = {eng}, issn = {0009-2770}, journal = {CHEMICKÉ LISTY}, title = {Comparative genomics of pathogenic Treponema pallidum subspecies}, volume = {2003}, year = {2003} }
TY - JOUR ID - 571749 AU - Matějková, Petra - Šmajs, David - Norris, SJ - Weinstock, GM PY - 2003 TI - Comparative genomics of pathogenic Treponema pallidum subspecies JF - CHEMICKÉ LISTY VL - 2003 IS - 97 SP - 297-298 EP - 297-298 PB - Česká společnost chemická SN - 00092770 KW - comparative genomics KW - Treponema pallidum N2 - DNA of Treponema pallidum subsp. pallidum Nichols strain was compared to DNA isolated from three different strains of T. pallidum subsp. pertenue (strain Gauthier, Samoan D, CDC-2). As a result of DNA microarray comparisons, 25 genes (13 with stronger and 6 with weaker signal in pertenue strains and 6 control genes with similar signal in both subspecies examined) were selected and sequenced. Altogether, 24083 nucleotides (2.12% of the genome) were sequenced in 3 pertenue strains and control Nichols. No region of extensive sequence heterogeneity was detected. However, 15 different single nucleotide polymorfisms (SNP) were identified: 3 SNPs in Gauthier strain, 14 in Samoan D and 15 SNPs in CDC-2. Ten (out of 15) SNPs cause amino acid changes. SNPs common for all pertenue strains as well as SNPs specific for each individual strain will allow to use these nucleotide polymorfisms to design sequence specific PCR diagnostics of these strains. ER -
MATĚJKOVÁ, Petra, David ŠMAJS, SJ NORRIS a GM WEINSTOCK. Comparative genomics of pathogenic Treponema pallidum subspecies. \textit{CHEMICKÉ LISTY}. Praha: Česká společnost chemická, 2003, roč.~2003, č.~97, s.~297-298. ISSN~0009-2770.
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