Age related changes of baroreflex sensitivity in children and adolescents

ZÁVODNÁ, Eva, Hana HRSTKOVÁ, Zuzana NOVÁKOVÁ, Bohumil FIŠER and Nataša HONZÍKOVÁ. Age related changes of baroreflex sensitivity in children and adolescents. In 14th Meeting of Paediatric Research of Cenral European Countries. 2005.

Basic information

• Original name: Age related changes of baroreflex sensitivity in children and adolescents
• Name in Czech: Na věku závislé změny baroreflexní citlivosti u dětí a dospívajících
• Name (in English): Age related changes of baroreflex sensitivity in children and adolescents
• Authors: ZÁVODNÁ, Eva (203 Czech Republic, guarantor), Hana HRSTKOVÁ (203 Czech Republic), Zuzana NOVÁKOVÁ (203 Czech Republic), Bohumil FIŠER (203 Czech Republic) and Nataša HONZÍKOVÁ (203 Czech Republic).
• Edition: 14th Meeting of Paediatric Research of Cenral European Countries, 2005.

Other information

• Original language: Czech
• Type of outcome: Conference abstract
• Field of Study: 30105 Physiology
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• RIV identification code: RIV/00216224:14110/05:00013798
• Organization unit: Faculty of Medicine
• Keywords in English: baroreflex sensitivity; developemnt; children; adolescents
• Tags: Adolescents, baroreflex sensitivity, children, developemnt

Abstract

The aim of the study was to investigate the development of noninvasively determined baroreflex sensitivity in age between 11 to 18 years. Continuous 5 min blood pressure readings were recorded in 332 healthy subjects. Beat-to-beat values of inter beat intervals (IBI), systolic blood pressures (SBP) were measured. Baroreflex sensitivity in ms/mmHg (BRS) and in mHz/mmHg (BRSf) was determined by spectral analysis. BRS did not correlate with age, BRSf significantly decrease with age (p<0.001). BRS correlated with mean IBI (p<0.001), but BRSf was IBI-independent. Multiregression analysis showed significant decrease of BRS with age after standardization to IBI. The limits of BRS were estimated for the whole group: 5th percentile - 3.9 ms/mmHg; 50th - 9.1; 95th - 18.9. BRS was unchanged in particular age groups, but it was dependent on IBI. Standardization of BRS on IBI disclosed its decrease with age. BRSf is IBI-independent and better reflects the development of baroreflex sensitivity with age.

Abstract (in English)

The aim of the study was to investigate the development of noninvasively determined baroreflex sensitivity in age between 11 to 18 years. Continuous 5 min blood pressure readings were recorded in 332 healthy subjects. Beat-to-beat values of inter beat intervals (IBI), systolic blood pressures (SBP) were measured. Baroreflex sensitivity in ms/mmHg (BRS) and in mHz/mmHg (BRSf) was determined by spectral analysis. BRS did not correlate with age, BRSf significantly decrease with age (p<0.001). BRS correlated with mean IBI (p<0.001), but BRSf was IBI-independent. Multiregression analysis showed significant decrease of BRS with age after standardization to IBI. The limits of BRS were estimated for the whole group: 5th percentile - 3.9 ms/mmHg; 50th - 9.1; 95th - 18.9. BRS was unchanged in particular age groups, but it was dependent on IBI. Standardization of BRS on IBI disclosed its decrease with age. BRSf is IBI-independent and better reflects the development of baroreflex sensitivity with age.

Links

• MSM0021622402, plan (intention): Name: Časná diagnostika a léčba kardiovaskulárních chorob

Investor: Ministry of Education, Youth and Sports of the CR, Early diagnostics and treatment of cardiovascular diseases

• NR8006, research and development project: Name: Autonomní oběhové funkce, funkce myokardu a kardiorespirační funkce u dětí a adolescentů po léčbě zhoubného nádoru

Investor: Ministry of Health of the CR