| HAVELKOVÁ, Marie, Pavel MENŠÍK a Eberhard UNGER. The role of calmodulin in cell cycle. Journal of APPLIED BIOMEDICINE. Czech Republic: University of South Bohemia, 2005, roč. 2005/3, 3 Suppl., s. S17-S18, 2 s. ISSN 1214-0287. |
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@article{578981,
author = {Havelková, Marie and Menšík, Pavel and Unger, Eberhard},
article_location = {Czech Republic},
article_number = {3 Suppl.},
keywords = {Calmodulin; cell cycle; Ca2+; indirect immunofluorescence; anti-calmodulin antibody; rhodamine-conjugated phalloidin; cytoskeletal actin; karyokinesis;},
language = {eng},
issn = {1214-0287},
journal = {Journal of APPLIED BIOMEDICINE},
title = {The role of calmodulin in cell cycle.},
volume = {2005/3},
year = {2005}
}
TY - JOUR
ID - 578981
AU - Havelková, Marie - Menšík, Pavel - Unger, Eberhard
PY - 2005
TI - The role of calmodulin in cell cycle.
JF - Journal of APPLIED BIOMEDICINE
VL - 2005/3
IS - 3 Suppl.
SP - S17-S18
EP - S17-S18
PB - University of South Bohemia
SN - 12140287
KW - Calmodulin
KW - cell cycle
KW - Ca2+
KW - indirect immunofluorescence
KW - anti-calmodulin antibody
KW - rhodamine-conjugated phalloidin
KW - cytoskeletal actin
KW - karyokinesis;
N2 - Calmodulin is a small, highly conserved, Ca2+-binding protein present in all eukaryotic cells. It is one of the mediators of Ca2+ signals induced by extracellular stimuli. Several lines of evidence have suggested that calmodulin is essential for eukaryotic cell proliferation. The intracellular localization of protein calmodulin and cytoskeletal actin in cells of yeast strain Yarrowia lipolytica has been studied by indirect immunofluorescence using anti-calmodulin antibody and rhodamine-conjugated phalloidin. We have found that there exist relationships between cytoskeletal components and protein calmodulin. Results: 1) the accumulation of calmodulin dots at the regions of cell growth suggests that this protein is important for cell polarity development in yeast; 2) calmodulin emerges in mentioned parts of the cell always sooner than actin. It proves that calmodulin is required for distribution of actin structures; 3) calmodulin is unconditionally needed for nuclear division.
ER -
HAVELKOVÁ, Marie, Pavel MENŠÍK a Eberhard UNGER. The role of calmodulin in cell cycle. \textit{Journal of APPLIED BIOMEDICINE}. Czech Republic: University of South Bohemia, 2005, roč.~2005/3, 3 Suppl., s.~S17-S18, 2 s. ISSN~1214-0287.
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