| PISTOVČÁKOVÁ, Jana, Aikaterina MAKATSORI, Alexandra ŠULCOVÁ a Daniela JEŽOVÁ. Felbamate reduces hormone release and locomotor hypoactivity induced by repeated stress of social defeat in mice. European Neuropsychopharmacology. Amsterdam: Elsevier B.V./ECNP, 2005, roč. 15, č. 2, s. 153-158. ISSN 0924-977X. |
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@article{581881,
author = {Pistovčáková, Jana and Makatsori, Aikaterina and Šulcová, Alexandra and Ježová, Daniela},
article_location = {Amsterdam},
article_number = {2},
keywords = {felbamate; stress hormones; social defeat; depression; mice; locomotor activity; open field},
language = {eng},
issn = {0924-977X},
journal = {European Neuropsychopharmacology},
title = {Felbamate reduces hormone release and locomotor hypoactivity induced by repeated stress of social defeat in mice},
volume = {15},
year = {2005}
}
TY - JOUR
ID - 581881
AU - Pistovčáková, Jana - Makatsori, Aikaterina - Šulcová, Alexandra - Ježová, Daniela
PY - 2005
TI - Felbamate reduces hormone release and locomotor hypoactivity induced by repeated stress of social defeat in mice
JF - European Neuropsychopharmacology
VL - 15
IS - 2
SP - 153-158
EP - 153-158
PB - Elsevier B.V./ECNP
SN - 0924977X
KW - felbamate
KW - stress hormones
KW - social defeat
KW - depression
KW - mice
KW - locomotor activity
KW - open field
N2 - A mouse model of repeated social defeat (nonaggressive male mouse repeatedly defeated by aggressive counterparts) was used. The results showed that acute treatment with felbamate, an antiepileptic drug modulating glutamatergic neurotransmission, reduced hypolocomotion in an open field induced by repeated social conflict. The same stress procedure resulted in increased release of corticosterone and dopamine. Felbamate decreased noradrenaline concentrations and inhibited stress-induced rise in corticosterone and dopamine. It is suggested that modulation of stress hormone release may be induced by the action of felbamate on glutamate neurotransmission, and neuroendocrine changes could contribute to behavioural effects of the drug.
ER -
PISTOVČÁKOVÁ, Jana, Aikaterina MAKATSORI, Alexandra ŠULCOVÁ a Daniela JEŽOVÁ. Felbamate reduces hormone release and locomotor hypoactivity induced by repeated stress of social defeat in mice. \textit{European Neuropsychopharmacology}. Amsterdam: Elsevier B.V./ECNP, 2005, roč.~15, č.~2, s.~153-158. ISSN~0924-977X.
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