A polymorphism in exon of the CD14 gene and atopic phenotypes
in Czech young patients with IgE-mediated allergy

D 2005

A polymorphism in exon of the CD14 gene and atopic phenotypes in Czech young patients with IgE-mediated allergy

BUČKOVÁ, Dana, Lydie IZAKOVIČOVÁ HOLLÁ a Vladimír ZNOJIL

Základní údaje

Originální název

A polymorphism in exon of the CD14 gene and atopic phenotypes in Czech young patients with IgE-mediated allergy

Název česky

Polymorfizmus v exonu genu pro CD14 receptor u mladých atopických pacientů v české populaci

Autoři

BUČKOVÁ, Dana, Lydie IZAKOVIČOVÁ HOLLÁ a Vladimír ZNOJIL

Vydání

Moscow, Russia, International Journal on Immunorehabilitation, od s. 74-74, 1 s. 2005

Nakladatel

III European Asthma Congress

Další údaje

Jazyk

angličtina

Typ výsledku

Stať ve sborníku

Obor

30102 Immunology

Stát vydavatele

Řecko

Utajení

není předmětem státního či obchodního tajemství

Organizační jednotka

Lékařská fakulta

ISBN

1562-3629

Klíčová slova anglicky

CD14; gene; polymorphism; IgE; allergy

Štítky

allergy, CD14, gene, IgE, polymorphism

Změněno: 26. 10. 2005 14:40, MUDr. Dana Bučková, Ph.D.

Anotace

ORIG CZ

V originále

Atopy is a generally considered to be caused by interaction of genetic and environmental factors. The gene encoding CD14 is a positional candidate gene for atopy, as it is localized on chromosome 5q31.1, a region that has been linked to asthma and atopic responses. We investigated relationship among atopic phenotypes and the 1341G/T polymorphism in exon of the CD14 gene in the Czech population. Polymerase chain reaction with RFLP analyses were used to determine the CD14 genotypes in subjects with IgE-mediated allergic diseases (n = 290) and random controls (n = 189). IgE-mediated allergy was recognised by specific IgE or a positive skin prick test to any one or more allergens. The CD14 allele or genotype distributions were similar in patients and control group. However, when atopic patients were subdivided in subjects with positive and those with negative skin prick tests, this polymorphism was significantly associated with a positive reactivity to the mites. T allele of the 1341G/T polymorphism were higher in patients with positive skin prick tests for mites than in patients without reactivity to this antigen (Pcorr<0.01).

Česky

Gen kódující CD14 receptor je kandidátním genem pro atopii vzhledem ke své poloze na chromozomu 5q. V této studii byla nalezena asociace 1341G/T polymorfizmu v CD14 genu s atopickým fenotypem v české populaci.

Návaznosti

GP310/03/D193, projekt VaV

Název: Úloha polymorfizmů v genech pro receptory CD14 a TLR4 u atopických nemocí v české populaci

Investor: Grantová agentura ČR, Úloha polymorfizmů v genech pro receptory CD14 a TLR4 u atopických nemocí v české populaci

Citovat

BUČKOVÁ, Dana, Lydie IZAKOVIČOVÁ HOLLÁ a Vladimír ZNOJIL. A polymorphism in exon of the CD14 gene and atopic phenotypes in Czech young patients with IgE-mediated allergy. In International Journal on Immunorehabilitation. Moscow, Russia: III European Asthma Congress, 2005, s. 74-74. ISBN 1562-3629.

@inproceedings{584802,
   author = {Bučková, Dana and Izakovičová Hollá, Lydie and Znojil, Vladimír},
   address = {Moscow, Russia},
   booktitle = {International Journal on Immunorehabilitation},
   keywords = {CD14; gene; polymorphism; IgE; allergy},
   language = {eng},
   location = {Moscow, Russia},
   isbn = {1562-3629},
   pages = {74-74},
   publisher = {III European Asthma Congress},
   title = {A polymorphism in exon of the CD14 gene and atopic phenotypes in Czech young patients with IgE-mediated allergy},
   year = {2005}
}

TY  - JOUR
ID  - 584802
AU  - Bučková, Dana - Izakovičová Hollá, Lydie - Znojil, Vladimír
PY  - 2005
TI  - A polymorphism in exon of the CD14 gene and atopic phenotypes in Czech young patients with IgE-mediated allergy
PB  - III European Asthma Congress
CY  - Moscow, Russia
SN  - 15623629
KW  - CD14
KW  - gene
KW  - polymorphism
KW  - IgE
KW  - allergy
N2  - Atopy is a generally considered to be caused by interaction of genetic and environmental factors. The gene encoding CD14 is a positional candidate gene for atopy, as it is localized on chromosome 5q31.1, a region that has been linked to asthma and atopic responses. We investigated relationship among atopic phenotypes and the 1341G/T polymorphism in exon of the CD14 gene in the Czech population. Polymerase chain reaction with RFLP analyses were used to determine the CD14 genotypes in subjects with IgE-mediated allergic diseases (n = 290) and random controls (n = 189). IgE-mediated allergy was recognised by specific IgE or a positive skin prick test to any one or more allergens. The CD14 allele or genotype distributions were similar in patients and control group. However, when atopic patients were subdivided in subjects with positive and those with negative skin prick tests, this polymorphism was significantly associated with a positive reactivity to the mites. T allele of the 1341G/T polymorphism were higher in patients with positive skin prick tests for mites than in patients without reactivity to this antigen (Pcorr<0.01).
ER  -

BUČKOVÁ, Dana, Lydie IZAKOVIČOVÁ HOLLÁ a Vladimír ZNOJIL. A polymorphism in exon of the CD14 gene and atopic phenotypes in Czech young patients with IgE-mediated allergy. In \textit{International Journal on Immunorehabilitation}. Moscow, Russia: III European Asthma Congress, 2005, s.~74-74. ISBN~1562-3629.

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