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@inproceedings{588643, author = {Krejci, Lumir and Etchin, Julia and Filippo, San Joe and Sung, Patrick}, address = {Philadelphia, USA}, booktitle = {Era of Hope 2005 - Department of Defense Breast Cancer Research Program Meeting}, keywords = {DNA repair; recombination; breast cancer; BRCA2; DNA binding}, language = {eng}, location = {Philadelphia, USA}, publisher = {U.S. Army Medical Research and Materiel Command}, title = {DNA Binding and Strand Annealing Properties of the Human BRCA2 DNA Binding Domain}, url = {https://www.seeuthere.com/rsvp/invitation/invitation.asp?id=/m2c640-853359890244}, year = {2005} }
TY - JOUR ID - 588643 AU - Krejci, Lumir - Etchin, Julia - Filippo, San Joe - Sung, Patrick PY - 2005 TI - DNA Binding and Strand Annealing Properties of the Human BRCA2 DNA Binding Domain PB - U.S. Army Medical Research and Materiel Command CY - Philadelphia, USA KW - DNA repair KW - recombination KW - breast cancer KW - BRCA2 KW - DNA binding UR - https://www.seeuthere.com/rsvp/invitation/invitation.asp?id=/m2c640-853359890244 L2 - https://www.seeuthere.com/rsvp/invitation/invitation.asp?id=/m2c640-853359890244 N2 - Mutations in the BRCA2 (breast cancer susceptibility gene 2) gene give rise to a significant portion of familial breast cancers. BRCA2 associates with Rad51, a key member of the RAD52 group, through a series of conserved modules called BRC repeats. Rad51 has a recombinase activity that mediates the formation of DNA joints between the injured chromosome and an intact homologue during HR. In mediating HR reactions, Rad51 nucleates onto single-stranded (ss) DNA derived from lesion processing to form a highly ordered nucleoprotein filament structure, often referred to as the presynaptic filament. After locating a DNA homologue, the presynaptic filament catalyzes pairing with the homologue to form a nascent DNA joint called a D-loop, the length of which is extended by DNA strand exchange. Concurrently, DNA synthesis commences to replace the genetic information lost during the lesion processing step. Subsequent steps include resolution of recombination intermediates and ligation to complete the recombination/repair reaction. ER -
KREJCI, Lumir, Julia ETCHIN, San Joe FILIPPO a Patrick SUNG. DNA Binding and Strand Annealing Properties of the Human BRCA2 DNA Binding Domain. In \textit{Era of Hope 2005 - Department of Defense Breast Cancer Research Program Meeting}. Philadelphia, USA: U.S. Army Medical Research and Materiel Command, 2005, 89 s.
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