DNA Binding and Strand Annealing Properties of the Human BRCA2 DNA Binding Domain

KREJCI, Lumir, Julia ETCHIN, San Joe FILIPPO a Patrick SUNG. DNA Binding and Strand Annealing Properties of the Human BRCA2 DNA Binding Domain. In Era of Hope 2005 - Department of Defense Breast Cancer Research Program Meeting. Philadelphia, USA: U.S. Army Medical Research and Materiel Command, 2005, 89 s.

Základní údaje

Originální název

DNA Binding and Strand Annealing Properties of the Human BRCA2 DNA Binding Domain

Název česky

DNA vazebné a hybridizacní vlastnosti DNA vazebne doménz lidského BRCA2 proteinu

Autoři

KREJCI, Lumir, Julia ETCHIN, San Joe FILIPPO a Patrick SUNG

Vydání

Philadelphia, USA, Era of Hope 2005 - Department of Defense Breast Cancer Research Program Meeting, 89 s. 2005

Nakladatel

U.S. Army Medical Research and Materiel Command

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Další údaje

Jazyk

angličtina

Typ výsledku

Stať ve sborníku

Obor

10600 1.6 Biological sciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

DNA repair; recombination; breast cancer; BRCA2; DNA binding

Štítky

BRCA2, breast cancer, DNA binding, DNA repair, recombination

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Anotace

V originále

Mutations in the BRCA2 (breast cancer susceptibility gene 2) gene give rise to a significant portion of familial breast cancers. BRCA2 associates with Rad51, a key member of the RAD52 group, through a series of conserved modules called BRC repeats. Rad51 has a recombinase activity that mediates the formation of DNA joints between the injured chromosome and an intact homologue during HR. In mediating HR reactions, Rad51 nucleates onto single-stranded (ss) DNA derived from lesion processing to form a highly ordered nucleoprotein filament structure, often referred to as the presynaptic filament. After locating a DNA homologue, the presynaptic filament catalyzes pairing with the homologue to form a nascent DNA joint called a D-loop, the length of which is extended by DNA strand exchange. Concurrently, DNA synthesis commences to replace the genetic information lost during the lesion processing step. Subsequent steps include resolution of recombination intermediates and ligation to complete the recombination/repair reaction.

Česky

Mutations in the BRCA2 (breast cancer susceptibility gene 2) gene give rise to a significant portion of familial breast cancers. BRCA2 associates with Rad51, a key member of the RAD52 group, through a series of conserved modules called BRC repeats. Rad51 has a recombinase activity that mediates the formation of DNA joints between the injured chromosome and an intact homologue during HR. In mediating HR reactions, Rad51 nucleates onto single-stranded (ss) DNA derived from lesion processing to form a highly ordered nucleoprotein filament structure, often referred to as the presynaptic filament. After locating a DNA homologue, the presynaptic filament catalyzes pairing with the homologue to form a nascent DNA joint called a D-loop, the length of which is extended by DNA strand exchange. Concurrently, DNA synthesis commences to replace the genetic information lost during the lesion processing step. Subsequent steps include resolution of recombination intermediates and ligation to complete the recombination/repair reaction.

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Návaznosti

MSM0021622413, záměr

Název: Proteiny v metabolismu a při interakci organismů s prostředím Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Proteiny v metabolismu a při interakci organismů s prostředím