2005
The relationship between the carotid intima-media thickness, baroreflex sensitivity, variability in blood pressure and heart rate, and ejection fraction in normotensives and hypertensives
LÁBROVÁ, Růžena, Nataša HONZÍKOVÁ, Bohumil FIŠER, Eva MADĚROVÁ, Petra VYSOČANOVÁ et. al.Základní údaje
Originální název
The relationship between the carotid intima-media thickness, baroreflex sensitivity, variability in blood pressure and heart rate, and ejection fraction in normotensives and hypertensives
Název česky
VZTAH MEZI TLOUŠŤKOU STĚNY A.CAROTIS, CITLIVOSTÍ BAROREFLEXU, VARIABILITOU V KREVNÍM TLAKU A SRDEČNÍ FREKVENCI A EJEKČNÍ FRAKCÍ U NORMOTONIKŮ A HYPERTONIKŮ
Název anglicky
The relationship between the carotid intima-media thickness, baroreflex sensitivity, variability in blood pressure and heart rate, and ejection fraction in normotensives and hypertensives
Autoři
LÁBROVÁ, Růžena (203 Česká republika, garant), Nataša HONZÍKOVÁ (203 Česká republika), Bohumil FIŠER (203 Česká republika), Eva MADĚROVÁ (203 Česká republika), Petra VYSOČANOVÁ (203 Česká republika), Zuzana NOVÁKOVÁ (203 Česká republika), Miroslav JÍRA (203 Česká republika) a Bořivoj SEMRÁD (203 Česká republika)
Vydání
Scripta medica, Brno, LF MU Brno, 2005, 1211-3395
Další údaje
Jazyk
čeština
Typ výsledku
Článek v odborném periodiku
Obor
30105 Physiology
Stát vydavatele
Česká republika
Utajení
není předmětem státního či obchodního tajemství
Kód RIV
RIV/00216224:14110/05:00014205
Organizační jednotka
Lékařská fakulta
Klíčová slova česky
Tloušťka intima-media, Baroreflex
Klíčová slova anglicky
Carotid intima-media thickness; Baroreflex sensitivity; Heart rate variability; Blood pressure variability
Štítky
Změněno: 19. 6. 2009 11:59, prof. MUDr. Bohumil Fišer, CSc.
V originále
A complex analysis of relationship between carotid intima-media thickness (IMT) and baroreflex sensitivity was performed in normotensives and hypertensives with respect to the signs of tonic and reflex autonomic control of heart rate and blood pressure (BP). The hierarchical multiple regression analysis by means of the forward selection of regressors proved an additive positive effect of age and BMI on a development of IMT in normotensives, but the influence of mean BP was insignificant . The same analysis performed in hypertensives showed, that their thick IMT is not further influenced neither by age nor by BMI nor by mean BP. Taking all subjects together, the dependence of IMT on age and mean BP from 24-h recordings was shown. Correlation of IMT with BRS and BRSf confirmed the hypothesis that the thickened carotid wall has lower compliance and therefore baroreflex sensitivity is lower. IMT correlates with many indices, but the increase of IMT in healthy subjects is dependent on age and BMI. BP plays a role besides age in thickening of carotid wall during the development of hypertension. It is probable that therapy in hypertonics decreases only sympathetic activation, but decreased BRS which is a risk factor for sudden cardiac death after myocardial infarction is not influenced by therapy.
Anglicky
A complex analysis of relationship between carotid intima-media thickness (IMT) and baroreflex sensitivity was performed in normotensives and hypertensives with respect to the signs of tonic and reflex autonomic control of heart rate and blood pressure (BP).The hierarchical multiple regression analysis by means of the forward selection of regressors proved an additive positive effect of age and BMI on a development of IMT in normotensives, but the influence of mean BP was insignificant . The same analysis performed in hypertensives showed, that their thick IMT is not further influenced neither by age nor by BMI nor by mean BP. Taking all subjects together, the dependence of IMT on age and mean BP from 24-h recordings was shown. Correlation of IMT with BRS and BRSf confirmed the hypothesis that the thickened carotid wall has lower compliance and therefore baroreflex sensitivity is lower. IMT correlates with many indices, but the increase of IMT in healthy subjects is dependent on age and BMI. BP plays a role besides age in thickening of carotid wall during the development of hypertension. It is probable that therapy in hypertonics decreases only sympathetic activation, but decreased BRS which is a risk factor for sudden cardiac death after myocardial infarction is not influenced by therapy.
Návaznosti
MSM0021622402, záměr |
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NA7362, projekt VaV |
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