J 2005

The relationship between the carotid intima-media thickness, baroreflex sensitivity, variability in blood pressure and heart rate, and ejection fraction in normotensives and hypertensives

LÁBROVÁ, Růžena, Nataša HONZÍKOVÁ, Bohumil FIŠER, Eva MADĚROVÁ, Petra VYSOČANOVÁ et. al.

Základní údaje

Originální název

The relationship between the carotid intima-media thickness, baroreflex sensitivity, variability in blood pressure and heart rate, and ejection fraction in normotensives and hypertensives

Název česky

VZTAH MEZI TLOUŠŤKOU STĚNY A.CAROTIS, CITLIVOSTÍ BAROREFLEXU, VARIABILITOU V KREVNÍM TLAKU A SRDEČNÍ FREKVENCI A EJEKČNÍ FRAKCÍ U NORMOTONIKŮ A HYPERTONIKŮ

Název anglicky

The relationship between the carotid intima-media thickness, baroreflex sensitivity, variability in blood pressure and heart rate, and ejection fraction in normotensives and hypertensives

Autoři

LÁBROVÁ, Růžena (203 Česká republika, garant), Nataša HONZÍKOVÁ (203 Česká republika), Bohumil FIŠER (203 Česká republika), Eva MADĚROVÁ (203 Česká republika), Petra VYSOČANOVÁ (203 Česká republika), Zuzana NOVÁKOVÁ (203 Česká republika), Miroslav JÍRA (203 Česká republika) a Bořivoj SEMRÁD (203 Česká republika)

Vydání

Scripta medica, Brno, LF MU Brno, 2005, 1211-3395

Další údaje

Jazyk

čeština

Typ výsledku

Článek v odborném periodiku

Obor

30105 Physiology

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Kód RIV

RIV/00216224:14110/05:00014205

Organizační jednotka

Lékařská fakulta

Klíčová slova česky

Tloušťka intima-media, Baroreflex

Klíčová slova anglicky

Carotid intima-media thickness; Baroreflex sensitivity; Heart rate variability; Blood pressure variability
Změněno: 19. 6. 2009 11:59, prof. MUDr. Bohumil Fišer, CSc.

Anotace

V originále

A complex analysis of relationship between carotid intima-media thickness (IMT) and baroreflex sensitivity was performed in normotensives and hypertensives with respect to the signs of tonic and reflex autonomic control of heart rate and blood pressure (BP). The hierarchical multiple regression analysis by means of the forward selection of regressors proved an additive positive effect of age and BMI on a development of IMT in normotensives, but the influence of mean BP was insignificant . The same analysis performed in hypertensives showed, that their thick IMT is not further influenced neither by age nor by BMI nor by mean BP. Taking all subjects together, the dependence of IMT on age and mean BP from 24-h recordings was shown. Correlation of IMT with BRS and BRSf confirmed the hypothesis that the thickened carotid wall has lower compliance and therefore baroreflex sensitivity is lower. IMT correlates with many indices, but the increase of IMT in healthy subjects is dependent on age and BMI. BP plays a role besides age in thickening of carotid wall during the development of hypertension. It is probable that therapy in hypertonics decreases only sympathetic activation, but decreased BRS which is a risk factor for sudden cardiac death after myocardial infarction is not influenced by therapy.

Anglicky

A complex analysis of relationship between carotid intima-media thickness (IMT) and baroreflex sensitivity was performed in normotensives and hypertensives with respect to the signs of tonic and reflex autonomic control of heart rate and blood pressure (BP).The hierarchical multiple regression analysis by means of the forward selection of regressors proved an additive positive effect of age and BMI on a development of IMT in normotensives, but the influence of mean BP was insignificant . The same analysis performed in hypertensives showed, that their thick IMT is not further influenced neither by age nor by BMI nor by mean BP. Taking all subjects together, the dependence of IMT on age and mean BP from 24-h recordings was shown. Correlation of IMT with BRS and BRSf confirmed the hypothesis that the thickened carotid wall has lower compliance and therefore baroreflex sensitivity is lower. IMT correlates with many indices, but the increase of IMT in healthy subjects is dependent on age and BMI. BP plays a role besides age in thickening of carotid wall during the development of hypertension. It is probable that therapy in hypertonics decreases only sympathetic activation, but decreased BRS which is a risk factor for sudden cardiac death after myocardial infarction is not influenced by therapy.

Návaznosti

MSM0021622402, záměr
Název: Časná diagnostika a léčba kardiovaskulárních chorob
Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Časná diagnostika a léčba kardiovaskulárních chorob
NA7362, projekt VaV
Název: VZTAH CITLIVOSTI BAROREFLEXU K PARAMETRŮM STĚNY A. CAROTIS ZJIŠŤOVANÝM SONOGRAFICKY
Investor: Ministerstvo zdravotnictví ČR, Vztah citlivosti baroreflexu k parametrům stěny A. Carotis zjišťovaným sonograficky