2006
Polymorphism of DRD2 gene and ADHD
ŠERÝ, Omar, Ivana DRTÍLKOVÁ, Pavel THEINER, Renáta PITELOVÁ, Radim ŠTAIF et. al.Základní údaje
Originální název
Polymorphism of DRD2 gene and ADHD
Název česky
Polymorfizmum genu pro DRD2 a ADHD
Název anglicky
Polymorphism of DRD2 gene and ADHD
Autoři
ŠERÝ, Omar (203 Česká republika, garant), Ivana DRTÍLKOVÁ (203 Česká republika), Pavel THEINER (203 Česká republika), Renáta PITELOVÁ (203 Česká republika), Radim ŠTAIF (203 Česká republika), Vladimír ZNOJIL (203 Česká republika) a Jan LOCHMAN (203 Česká republika)
Vydání
Neuroendocrinology Letters, Sweden, Stockholm, Maghira and Maas Publications, 2006, 0172-780X
Další údaje
Jazyk
čeština
Typ výsledku
Článek v odborném periodiku
Obor
30000 3. Medical and Health Sciences
Stát vydavatele
Česká republika
Utajení
není předmětem státního či obchodního tajemství
Impakt faktor
Impact factor: 0.924
Kód RIV
RIV/00216224:14310/06:00016583
Organizační jednotka
Přírodovědecká fakulta
UT WoS
000238667700040
Klíčová slova anglicky
ADHD; dopamine; DRD2; polymorphism; association; gene
Štítky
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 13. 2. 2008 17:32, prof. RNDr. Omar Šerý, Ph.D.
V originále
Objectives: Attention deficit hyperactivity disorder (ADHD) is a prevalent childhood disorder. Evidence from the family and twin studies suggest that ADHD is familiar and highly heritable. Association studies are frequently used for the searching of markers responsible for genetic basis of ADHD. We investigated TaqI polymorphism of the dopamine receptor D2 (DRD2) in relationship with ADHD. The association between TaqI A polymorphism of DRD2 gene and ADHD has previously been published. Design: We used the association study to test the relationship between TaqI A polymorphism of DRD2 gene and ADHD on groups of ADHD boys and control boys. Setting: For DNA isolation, buccal tissue was used. PCR with restriction analysis of PCR products was used for genotyping. Results: We found statistically different genotypic and allelic frequencies (p < 0,008, p < 0,002, respectively) of DRD2 polymorphism between two studied groups of boys. Main findings: According to our results we suppose that polymorphism TaqI A of DRD2 gene is involved in the pathogenesis of childhood ADHD in male subjects. Allele A1 and genotype A1A1 in male subjects is associated with ADHD. Conclusions: Our study confirmed the relationship between TaqI A polymorphism of DRD2 gene and ADHD published previously.
Anglicky
Objectives: Attention deficit hyperactivity disorder (ADHD) is a prevalent childhood disorder. Evidence from the family and twin studies suggest that ADHD is familiar and highly heritable. Association studies are frequently used for the searching of markers responsible for genetic basis of ADHD. We investigated TaqI polymorphism of the dopamine receptor D2 (DRD2) in relationship with ADHD. The association between TaqI A polymorphism of DRD2 gene and ADHD has previously been published. Design: We used the association study to test the relationship between TaqI A polymorphism of DRD2 gene and ADHD on groups of ADHD boys and control boys. Setting: For DNA isolation, buccal tissue was used. PCR with restriction analysis of PCR products was used for genotyping. Results: We found statistically different genotypic and allelic frequencies (p < 0,008, p < 0,002, respectively) of DRD2 polymorphism between two studied groups of boys. Main findings: According to our results we suppose that polymorphism TaqI A of DRD2 gene is involved in the pathogenesis of childhood ADHD in male subjects. Allele A1 and genotype A1A1 in male subjects is associated with ADHD. Conclusions: Our study confirmed the relationship between TaqI A polymorphism of DRD2 gene and ADHD published previously.
Návaznosti
| MSM0021622413, záměr |
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| NF6520, projekt VaV |
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