| BRYJA, Vítězslav, Lukáš ČAJÁNEK, Jiří PACHERNÍK, A.C. HALL, Viktor HORVÁTH, Petr DVOŘÁK a Aleš HAMPL. Abnormal development of mouse embryoid bodies lacking p27Kip1 cell cycle regulator. Stem Cells. 2005, roč. 23, č. 7, s. 965-974. ISSN 1066-5099. |
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@article{611385,
author = {Bryja, Vítězslav and Čajánek, Lukáš and Pacherník, Jiří and Hall, A.C. and Horváth, Viktor and Dvořák, Petr and Hampl, Aleš},
article_number = {7},
keywords = {cells},
language = {eng},
issn = {1066-5099},
journal = {Stem Cells},
title = {Abnormal development of mouse embryoid bodies lacking p27Kip1 cell cycle regulator.},
volume = {23},
year = {2005}
}
TY - JOUR
ID - 611385
AU - Bryja, Vítězslav - Čajánek, Lukáš - Pacherník, Jiří - Hall, A.C. - Horváth, Viktor - Dvořák, Petr - Hampl, Aleš
PY - 2005
TI - Abnormal development of mouse embryoid bodies lacking p27Kip1 cell cycle regulator.
JF - Stem Cells
VL - 23
IS - 7
SP - 965-974
EP - 965-974
SN - 10665099
KW - cells
N2 - Cultures of three-dimensional aggregates of embryonic stem (ES) cells called embryoid bodies (EBs) provide a valuable system for analyzing molecular mechanisms that regulate differentiation of this unique cell type. Cyclin dependent kinase inhibitor p27Kip1 (p27) becomes dramatically elevated during the differentiation of mouse ES (mES) cells. In this study, various aspects of differentiation of EBs produced from normal and p27-deficient mES cells were analyzed to address biological significance of this elevation. The data point to a dual role of p27 in mES cells, with one role beeing in the regulation of proliferation and the other role in establishing some other aspects of a differentiated phenotype.
ER -
BRYJA, Vítězslav, Lukáš ČAJÁNEK, Jiří PACHERNÍK, A.C. HALL, Viktor HORVÁTH, Petr DVOŘÁK a Aleš HAMPL. Abnormal development of mouse embryoid bodies lacking p27Kip1 cell cycle regulator. \textit{Stem Cells}. 2005, roč.~23, č.~7, s.~965-974. ISSN~1066-5099.
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