2005
Determination of Trinitrotoluenes and product of their Biotransformation using liquid chromatography and Capillary Electrophoresis
BEČANOVÁ, Jitka, Zdeněk ŠIMEK a Zdeněk FRIEDLZákladní údaje
Originální název
Determination of Trinitrotoluenes and product of their Biotransformation using liquid chromatography and Capillary Electrophoresis
Název česky
Stanovení trinitrotoluenů a produktů jejich biotransformace kapalinovou chromatografií a kapilární elektroforézou
Autoři
BEČANOVÁ, Jitka (203 Česká republika), Zdeněk ŠIMEK (203 Česká republika, garant) a Zdeněk FRIEDL (203 Česká republika)
Vydání
Chemické Listy, Praha, Česká společnost chemická, 2005, 0009-2770
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
10406 Analytical chemistry
Stát vydavatele
Česká republika
Utajení
není předmětem státního či obchodního tajemství
Impakt faktor
Impact factor: 0.445
Kód RIV
RIV/00216224:14310/05:00014637
Organizační jednotka
Přírodovědecká fakulta
Klíčová slova anglicky
Chromatogrphy; Electrophoresis; Trinitrotoluene
Štítky
Změněno: 31. 1. 2006 15:02, doc. RNDr. Zdeněk Šimek, CSc.
V originále
Contamination by the explosive as 2,4,6-trinitrotoluene (TNT), is often associated with former and present munitions manufacturing facilities, storage depots, and former sites of explosives use.1 TNT is widely distributed in enviroment and there can be persistent for very long times or slowly degradation in the water and in the soil, influenced by light, microorganisms, oxygen and reducing chemicals. TNT and their products of degradation, aminodinitrotoluenes (ADNT), diaminonitrotoluenes (DANT) and triaminotoluene (TAT) have been found to be cytotoxic presumably due to induced oxidative stress and demonstrate mutagenic capability (EPA classifies TNT as possible human carcinogens).2,3 Complete separation of these structurally similar compounds is necessary in order to their accurately determine and quantify in environmental samples and in (bio)transformation studies. High performance liquid chromatography (HPLC) has remained the major analytical tool for the detection and quantification of nitroaromatic compounds.4 At present, capillary electromigration methods, capillary electrochromatography (CEC) and micellar electrokinetic chromatography (MEKC) enable to separate these compound with good separation efficiency.
Česky
Contamination by the explosive as 2,4,6-trinitrotoluene (TNT), is often associated with former and present munitions manufacturing facilities, storage depots, and former sites of explosives use.1 TNT is widely distributed in enviroment and there can be persistent for very long times or slowly degradation in the water and in the soil, influenced by light, microorganisms, oxygen and reducing chemicals. TNT and their products of degradation, aminodinitrotoluenes (ADNT), diaminonitrotoluenes (DANT) and triaminotoluene (TAT) have been found to be cytotoxic presumably due to induced oxidative stress and demonstrate mutagenic capability (EPA classifies TNT as possible human carcinogens).2,3 Complete separation of these structurally similar compounds is necessary in order to their accurately determine and quantify in environmental samples and in (bio)transformation studies. High performance liquid chromatography (HPLC) has remained the major analytical tool for the detection and quantification of nitroaromatic compounds.4 At present, capillary electromigration methods, capillary electrochromatography (CEC) and micellar electrokinetic chromatography (MEKC) enable to separate these compound with good separation efficiency.
Návaznosti
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