2005
Effects of a persistent sodium current through mutated hNav1.5 sodium channels on intracellular ionic homeostasis in a ventricular cell model
CHRISTÉ, Georges; L. RESTIER; M. CHAHINE; P. CHEVALIER; Michal PÁSEK et. al.Basic information
Original name
Effects of a persistent sodium current through mutated hNav1.5 sodium channels on intracellular ionic homeostasis in a ventricular cell model
Name in Czech
Účinek persistentního sodíkového proudu přes mutované hNav1.5 sodíkové kanály na intracelulární iontovou rovnováhu v modelu komorové buňky
Authors
CHRISTÉ, Georges (250 France); L. RESTIER (250 France); M. CHAHINE (124 Canada); P. CHEVALIER (250 France) and Michal PÁSEK (203 Czech Republic, guarantor, belonging to the institution)
Edition
Lyon, Computers in cardiology 2005, p. 997-1000, 4 pp. 2005
Publisher
IEEE
Other information
Language
English
Type of outcome
Proceedings paper
Field of Study
30105 Physiology
Country of publisher
France
Confidentiality degree
is not subject to a state or trade secret
RIV identification code
RIV/00216224:14110/05:00019309
Organization unit
Faculty of Medicine
ISBN
0-7803-9337-6
ISSN
UT WoS
000236378300251
Keywords in English
cardiac cell persistent; sodium current; quantitative modelling
Changed: 27/4/2011 14:45, doc. Ing. Michal Pásek, Ph.D.
In the original language
In LQT3 patients, SCN5A mutations were found that lead to a small fraction of persistent hNav1.5 current. We explored the effects of such a change on the intracellular ionic homeostasis and arrhythmogenesis in a model of guinea-pig cardiac ventricular cell.
In Czech
SCN5A mutace sodíkových kanálů nalezené u pacientů se syndromem LQT3 způsobují vznik malé frakce persistentního hMav1.5 proudu. Cílem práce bylo vyšetřit účinek této mutace na intracelulární iontovou rovnováhu a arytmogenezi u modelu srdeční komorové buňky morčete.
Links
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| MSM0021622402, plan (intention) |
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