Polymorphisms of NMDA receptor, DRD2 receptor, GABA-A receptor and electrophysiologic variations found in BAEP and MLR in relation to tinnitus manifestation - update

ROTTENBERG, Jan, Miroslav ŽALLMANN, Rom KOSTŘICA and Michal JURAJDA. Polymorphisms of NMDA receptor, DRD2 receptor, GABA-A receptor and electrophysiologic variations found in BAEP and MLR in relation to tinnitus manifestation - update. In XVIII IFOS World Congress, Rome, 25-30 June, 2005. Rome, Italy: International Federation of Ot-Rhino-Laryngological Societies, 2005, p. 141.

Basic information

• Original name: Polymorphisms of NMDA receptor, DRD2 receptor, GABA-A receptor and electrophysiologic variations found in BAEP and MLR in relation to tinnitus manifestation - update
• Name in Czech: Polymorfismy NMDA receptoru, DRD-2 receptoru, GABA-A receptoru a variabilita odpovdí BAEP a MLRve vztahu k manifestaci tinnitu - aktualizovaná informace
• Authors: ROTTENBERG, Jan, Miroslav ŽALLMANN, Rom KOSTŘICA and Michal JURAJDA.
• Edition: Rome, Italy, XVIII IFOS World Congress, Rome, 25-30 June, 2005, p. 141-141, 2005.
• Publisher: International Federation of Ot-Rhino-Laryngological Societies

Other information

• Original language: English
• Type of outcome: Proceedings paper
• Field of Study: 30200 3.2 Clinical medicine
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• Organization unit: Faculty of Medicine
• Keywords in English: tinnitus manifestation
• Tags: tinnitus manifestation

Abstract

Prospective study of 105 patients demonstrate the associations between tinnitus manifestation (multiple data acquired by the tinnitus questionnaire) emotional lability, and Taq I polymorphism of the DRD-2, three single nucleotide polymorphism in GRIN2A subunit of the NMDA receptor and CA repeat in GABRB3 subunit of the GABA-A receptor and changes of amplitude in BAEP and MLR response waveforms which can signalize the desinhibition of the central auditory pathways. The statistically significant correlation between the tinnitus score and the V/III amplitude ratios at intensities 90-110 dB (p=0,001) The amplitude of Pa wave of MLR response correlates significantly with tinnitus score as well (p=0.001).The genetic analysis shows the difference of the tinnitus score according to genotypes of polymorphism CA repeat of GABRbeta3 subunit of GABA-A receptor (p=0,025), we have also found a difference of electrophysiological data according to the genotype in the polymorphism of GRIN2b PST (p=0,007). All tested polymorphisms have been verified to be consistent with the Hardy-Weinberg equilibrium.

Abstract (in Czech)

Prospektivní studie 105 pacient prokazující asociace mezi manifestací tinnitu (data získaná z dotazníku), emoní labilitou, Taq I polymorfismem DRD2 receptoru, 3 SN polymorfismy NMDA receptoru a CA repetitivní sekvencí GABA-A receptoru a zmnami v odpovdích BAEP a MLR, které mohou signalizovat desinhibici. Byl nalezen statisticky signifikantní vztah mezi pomrem amplitud vln V/III na intenzitách 90-110 dB (p=0,001). Amplituda vlny Pa korelovala rovnž s tinnitus skóre (p=0,001). Genetická analýza ukazuje signifikantní rozdíl v tinnitus skóre u CA repetitivní sekvence GABRbeta3 podjednotky GABA-A repceptoru (p=0,07) a rozdíl v elektrofyziologických odpovdích u polymorfismu GRIN2a PST (p=0,007). Všechny testované polymorfismy byly konzistentní s Hardy-Weinbergovým ekvilibriem.

Links

• NM7472, research and development project: Name: Elektrofyziologické a genetické aspekty tinnitu.