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@article{625085,
author = {Bednářová, Jana and Štourač, Pavel and Adam, Pavel},
article_number = {2},
keywords = {MRZ reaction;multiple sclerosis; neuroborreliosis; immunological variables},
language = {eng},
issn = {0001-6314},
journal = {Acta Neurologica Scandinavica},
title = {Relevance of immunological variables in neuroborreliosis and multiple sclerosis},
volume = {112/2005},
year = {2005}
}
TY - JOUR
ID - 625085
AU - Bednářová, Jana - Štourač, Pavel - Adam, Pavel
PY - 2005
TI - Relevance of immunological variables in neuroborreliosis and multiple sclerosis
JF - Acta Neurologica Scandinavica
VL - 112/2005
IS - 2
SP - 97-102
EP - 97-102
SN - 00016314
KW - MRZ reaction;multiple sclerosis
KW - neuroborreliosis
KW - immunological variables
N2 - The aims were to investigate the frequency of intrathecal synthesis of specific antibodies against measles (M), rubella(R),and varicella zoster (Z)viruses(MRZ reaction) as a diagnostic marker between multiple sclerosis (MS) and neuroborreliosis (NB)groups and to postulate the most typical cerebrospinal fluid (CSF) variables profile of these entities. Three cohorts of patients were investigated :MS (n=42),NB (n=27) and other neurological diseases (OND) (n=15).Measles, rubella varicella zoster and borrelia specific IgG antibodies were measured by ELISA , Qalb as a marker of blood -CSF barrier function and specific antibody indices (AI) were calculated according to relevant formulae. IgG oligoclonal bands (OB) were detected by isoelectric focusing and immunoenzymatic staining. Results : Eighty- eight percent of MS patients had positive MRZ reaction and 26.2% had positive anti -borrelia AI. Eighty -nine percent of NB patients had positive anti-borrelia AI and two patients had individually anti measles and rubella positive AI. -MS CSF variables profile included the presence of IgG OB in 81% ,elevated Qalb in 31% and normal cell count in 7. 4%. Conclusion -MRZ reaction was proved as statistically significant marker in differential diagnosis between MS and NB. Typical CSF variables profile of these two entities is highly supportive , escpecially when MRZ is included.
ER -
BEDNÁŘOVÁ, Jana, Pavel ŠTOURAČ a Pavel ADAM. Relevance of immunological variables in neuroborreliosis and multiple sclerosis. \textit{Acta Neurologica Scandinavica}. 2005, roč.~112/2005, č.~2, s.~97-102. ISSN~0001-6314.
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