Successful mobilization of peripheral blood stem cells with the
DHAP regimen (dexamethasone, cytarabine, cisplatinum) plus
granulocyte colony-stimulating factor in patients with relapsed
Hodgkin's disease

J 2005

Successful mobilization of peripheral blood stem cells with the DHAP regimen (dexamethasone, cytarabine, cisplatinum) plus granulocyte colony-stimulating factor in patients with relapsed Hodgkin's disease

ŠMARDOVÁ, Lenka, Andreas ENGERT, Hans HAVERKAMP, J. RAEMAKERS, J. BAARS et. al.

Basic information

Original name

Successful mobilization of peripheral blood stem cells with the DHAP regimen (dexamethasone, cytarabine, cisplatinum) plus granulocyte colony-stimulating factor in patients with relapsed Hodgkin's disease

Name in Czech

Mobilizace periferních kmenových buněk pomocí režimu DHAP (dexamethazon, cytarabin, cisplatina) a G-CSF u pacientů s relabovaným Hodgkinským lymfomem

Authors

ŠMARDOVÁ, Lenka, Andreas ENGERT, Hans HAVERKAMP, J. RAEMAKERS, J. BAARS, Beate PFISTNER, Volker DIEHL and Andreas JOSTING

Edition

LEUKEMIA & LYMPHOMA, 2005, 1042-8194

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30200 3.2 Clinical medicine

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.295

Organization unit

Faculty of Medicine

UT WoS

000230304000007

Keywords in English

stem cell mobilization; cells; DHAP; Hodgkin's lymphoma

Abstract

ORIG CZ

V originále

High-dose chemotherapy followed by autologous stem cell transplantation can improve the outcome of relapsed and refractory Hodgkins disease (HD) patients. The objective of the trial was to determine the mobilizing potential of the DHAP salvage regimen (dexamethasone, cytarabine, cisplatin) for the collection of peripheral blood stem cells (PBSC) in patients with relapsed HD. The target yield of harvesting CD34 + cells was more or = 2 x 10(6)/kg in order to support the subsequent myeloablative chemotherapy. Most of the 105 patients included were intensively pre-treated with different combination chemotherapy regimens prior to mobilization. The use of DHAP followed by granulocyte colony-stimulating factor (G-CSF; 10 microg/kg) resulted in the successful collection of adequate numbers of PBSC in 97.1% of patients (102 of 105) with a median harvest of CD34+ cells of 13 x 10(6)/kg (range 2.6 - 85.1). More than 2.0 x 10(6) CD34+ cells/kg were achieved in 65 of 103 (63%) patients after 1 apheresis, the maximum number of aphereses for all patients was 3. It was found that the optimal time of PBSC harvest was at days 13 - 16 after initiating the mobilization regimen. These results demonstrate that the salvage chemotherapy regimen, such as DHAP combined with G-CSF, can be successfully used to mobilize PBSC in HD patients.

In Czech

Mobilizace periferních kmenových buněk pomocí režimu DHAP (dexamethazon, cytarabin, cisplatina) a G-CSF u pacientů s relabovaným Hodgkinským lymfomem.

Citovat

ŠMARDOVÁ, Lenka, Andreas ENGERT, Hans HAVERKAMP, J. RAEMAKERS, J. BAARS, Beate PFISTNER, Volker DIEHL and Andreas JOSTING. Successful mobilization of peripheral blood stem cells with the DHAP regimen (dexamethasone, cytarabine, cisplatinum) plus granulocyte colony-stimulating factor in patients with relapsed Hodgkin's disease. LEUKEMIA & LYMPHOMA. 2005, vol. 46, No 7, p. 1017-1022. ISSN 1042-8194.

@article{633735,
   author = {Šmardová, Lenka and Engert, Andreas and Haverkamp, Hans and Raemakers, J. and Baars, J. and Pfistner, Beate and Diehl, Volker and Josting, Andreas},
   article_number = {7},
   keywords = {stem cell mobilization; cells; DHAP; Hodgkin's lymphoma},
   language = {eng},
   issn = {1042-8194},
   journal = {LEUKEMIA & LYMPHOMA},
   title = {Successful mobilization of peripheral blood stem cells with the DHAP regimen (dexamethasone, cytarabine, cisplatinum) plus granulocyte colony-stimulating factor in patients with relapsed Hodgkin's disease},
   volume = {46},
   year = {2005}
}

TY  - JOUR
ID  - 633735
AU  - Šmardová, Lenka - Engert, Andreas - Haverkamp, Hans - Raemakers, J. - Baars, J. - Pfistner, Beate - Diehl, Volker - Josting, Andreas
PY  - 2005
TI  - Successful mobilization of peripheral blood stem cells with the DHAP regimen (dexamethasone, cytarabine, cisplatinum) plus granulocyte colony-stimulating factor in patients with relapsed Hodgkin's disease
JF  - LEUKEMIA & LYMPHOMA
VL  - 46
IS  - 7
SP  - 1017-1022
EP  - 1017-1022
SN  - 10428194
KW  - stem cell mobilization
KW  - cells
KW  - DHAP
KW  - Hodgkin's lymphoma
N2  - High-dose chemotherapy followed by autologous stem cell transplantation can improve the outcome of relapsed and refractory Hodgkins disease (HD) patients. The objective of the trial was to determine the mobilizing potential of the DHAP salvage regimen (dexamethasone, cytarabine, cisplatin) for the collection of peripheral blood stem cells (PBSC) in patients with relapsed HD. The target yield of harvesting CD34 + cells was more or = 2 x 10(6)/kg in order to support the subsequent myeloablative chemotherapy. Most of the 105 patients included were intensively pre-treated with different combination chemotherapy regimens prior to mobilization. The use of DHAP followed by granulocyte colony-stimulating factor (G-CSF; 10 microg/kg) resulted in the successful collection of adequate numbers of PBSC in 97.1% of patients (102 of 105) with a median harvest of CD34+ cells of 13 x 10(6)/kg (range 2.6 - 85.1). More than 2.0 x 10(6) CD34+ cells/kg were achieved in 65 of 103 (63%) patients after 1 apheresis, the maximum number of aphereses for all patients was 3. It was found that the optimal time of PBSC harvest was at days 13 - 16 after initiating the mobilization regimen. These results demonstrate that the salvage chemotherapy regimen, such as DHAP combined with G-CSF, can be successfully used to mobilize PBSC in HD patients.
ER  -

ŠMARDOVÁ, Lenka, Andreas ENGERT, Hans HAVERKAMP, J. RAEMAKERS, J. BAARS, Beate PFISTNER, Volker DIEHL and Andreas JOSTING. Successful mobilization of peripheral blood stem cells with the DHAP regimen (dexamethasone, cytarabine, cisplatinum) plus granulocyte colony-stimulating factor in patients with relapsed Hodgkin's disease. \textit{LEUKEMIA \&{} LYMPHOMA}. 2005, vol.~46, No~7, p.~1017-1022. ISSN~1042-8194.

Detailed Information on Publication Record