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@inproceedings{693826,
author = {Beneš, Petr and Macečková, Vendula and Andrysík, Zdeněk and Zatloukalová, Jiřina and Šmarda, Jan},
address = {Pavia},
booktitle = {Haematologica/the hematology journal},
keywords = {okadaic acid; retinoic acid; differentiation; apoptosis; monoblast; v-Myb},
language = {eng},
location = {Pavia},
isbn = {0390-6078},
pages = {469-469},
publisher = {Ferrata Storti Foundation},
title = {Retinoic acid affects the response of v-Myb-transformed monoblasts to okadaic acid},
year = {2006}
}
TY - JOUR
ID - 693826
AU - Beneš, Petr - Macečková, Vendula - Andrysík, Zdeněk - Zatloukalová, Jiřina - Šmarda, Jan
PY - 2006
TI - Retinoic acid affects the response of v-Myb-transformed monoblasts to okadaic acid
PB - Ferrata Storti Foundation
CY - Pavia
SN - 03906078
KW - okadaic acid
KW - retinoic acid
KW - differentiation
KW - apoptosis
KW - monoblast
KW - v-Myb
N2 - The aim of this study was to explore the functional interaction of retinoic acid (RA)- and okadaic acid (OA)-driven pathways in v-Myb-transformed monoblasts BM2. We found that 10 nm OA induces adherency, cell cycle arrest, phagocytic activity, production of reactive oxygen species, and expression of vimentin in BM2 cells. These features that mark differentiation along monocyte/macrophage pathway are enhanced in BM2 cells upon simultaneous treatment with OA and RA. Interestingly, the 20 nm OA induces rather apoptosis than differentiation of BM2 cells. This pro-apopotic effect of OA was inhibited by RA. These results indicate that pro-differentiation and pro-apoptotic effects of OA on BM2 monoblasts are differently regulated by RA.
ER -
BENEŠ, Petr, Vendula MACEČKOVÁ, Zdeněk ANDRYSÍK, Jiřina ZATLOUKALOVÁ and Jan ŠMARDA. Retinoic acid affects the response of v-Myb-transformed monoblasts to okadaic acid. In \textit{Haematologica/the hematology journal}. Pavia: Ferrata Storti Foundation, 2006, p.~469-469. ISBN~0390-6078.
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