TOMANDL, Josef, Hana PAULOVÁ, Lenka ŠPINAROVÁ, Eva TÁBORSKÁ and Jindřich ŠPINAR. Serum matrix metalloproteinase (MMP-2) and its tissue inhibitor (TIMP-1) in relation to pro- and anti-fibrotic factors in patients with heart failure. In Proceedings from XX. Biochemický zjazd. Bratislava: Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, 2006, p. 358. ISBN 80-969532-6-5.
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Basic information
Original name Serum matrix metalloproteinase (MMP-2) and its tissue inhibitor (TIMP-1) in relation to pro- and anti-fibrotic factors in patients with heart failure
Name in Czech Sérová matrix metalloproteinasa (MMP-2) a její tkáňový inhibitor (TIMP-1) ve vztahu k pro- a anti-fibrotickým faktorům u pacientů se srdečním selháním
Authors TOMANDL, Josef (203 Czech Republic, guarantor), Hana PAULOVÁ (203 Czech Republic), Lenka ŠPINAROVÁ (203 Czech Republic), Eva TÁBORSKÁ (203 Czech Republic) and Jindřich ŠPINAR (203 Czech Republic).
Edition Bratislava, Proceedings from XX. Biochemický zjazd, p. 358-358, 2006.
Publisher Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences
Other information
Original language English
Type of outcome Proceedings paper
Field of Study 10600 1.6 Biological sciences
Country of publisher Slovakia
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14110/06:00017183
Organization unit Faculty of Medicine
ISBN 80-969532-6-5
Keywords in English metalloproteinase - tissue inhibitor - fibrotic factors - heart failure
Changed by Changed by: doc. RNDr. Josef Tomandl, Ph.D., učo 47. Changed: 18/9/2006 16:26.
Abstract
Matrix metalloproteinase MMP-2 and its endogenous inhibitor TIMP-1 are associated with extracellular matrix remodeling, which may lead to interstitial fibrosis and thus contribute to heart failure. Besides, pro- and anti-fibrotic factors such as endothelin-1 and nitric oxide, respectively, regulate fibrosis by modulating collagen synthesis and also MMP/TIMP activity. Nowadays, there is thought that progressive remodeling accompanied with changes in the extracellular matrix may lead to severe heart failure. The aim of this study was to find a relationship between MMP-2/TIMP-1 and other above mentioned parameters in patients with heart failure.
Abstract (in Czech)
Matrix metalloproteinase MMP-2 and its endogenous inhibitor TIMP-1 are associated with extracellular matrix remodeling, which may lead to interstitial fibrosis and thus contribute to heart failure. Besides, pro- and anti-fibrotic factors such as endothelin-1 and nitric oxide, respectively, regulate fibrosis by modulating collagen synthesis and also MMP/TIMP activity. Nowadays, there is thought that progressive remodeling accompanied with changes in the extracellular matrix may lead to severe heart failure. The aim of this study was to find a relationship between MMP-2/TIMP-1 and other above mentioned parameters in patients with heart failure.
Links
MSM0021622402, plan (intention)Name: Časná diagnostika a léčba kardiovaskulárních chorob
Investor: Ministry of Education, Youth and Sports of the CR, Early diagnostics and treatment of cardiovascular diseases
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