Endocannabinoid system activity and methamphetamine addiction

LANDA, Leoš, Karel ŠLAIS, Jana KUČEROVÁ and Alexandra ŠULCOVÁ. Endocannabinoid system activity and methamphetamine addiction. In Book of Abstracts. 2006.

Basic information

• Original name: Endocannabinoid system activity and methamphetamine addiction
• Name in Czech: Aktivita endokanabinoidního systému a metamfetaminová závislost
• Authors: LANDA, Leoš (203 Czech Republic, guarantor), Karel ŠLAIS (203 Czech Republic), Jana KUČEROVÁ (203 Czech Republic) and Alexandra ŠULCOVÁ (203 Czech Republic).
• Edition: Book of Abstracts, 2006.

Other information

• Original language: English
• Type of outcome: Conference abstract
• Field of Study: 30104 Pharmacology and pharmacy
• Country of publisher: Estonia
• Confidentiality degree: is not subject to a state or trade secret
• RIV identification code: RIV/00216224:14110/06:00017318
• Organization unit: Faculty of Medicine
• Keywords in English: behavioral sensitization; cannabinoids; methamphetamine; addiction
• Tags: addiction, behavioral sensitization, cannabinoids, methamphetamine
• Tags: International impact

Abstract

Cannabinoid CB1 receptor stimulation by an agonist cross-sensitized to metamphetamine, while blocking of the CB1 receptor with an antagonist during the sensitizing phase with methamphetamine suppressed this phenomenon. The CB2 receptor agonist eliciting in our model of aggressivity behavioural effects did not cause cross-sensitization to methamphetamine.

Abstract (in Czech)

Stimulace kanabinoidního receptoru CB1 agonistou vyvolala zkříženou senzitizaci k účinkům metamfetaminu, zatímco zablokování CB1 receptoru antagonistou během senzitizační fáze metamfetaminem, tento fenomén potlačilo. Agonista CB2 receptorů vyvolávající v našem modelu agresivity behaviorální účinky zkříženou senzitizaci k metamfetaminu nezpůsobil.

Links

• MSM0021622404, plan (intention): Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.