A case-control study of the relationship between 13 candidate
genes and ADHD

J 2006

A case-control study of the relationship between 13 candidate genes and ADHD

ŠTAIF, Radim, Omar ŠERÝ, Renáta PITELOVÁ, Jan LOCHMAN, Vladimír MIKEŠ et. al.

Základní údaje

Originální název

A case-control study of the relationship between 13 candidate genes and ADHD

Název česky

Asociační studie vztahu mezi 13 kandidátními geny a ADHD

Autoři

ŠTAIF, Radim (203 Česká republika), Omar ŠERÝ (203 Česká republika, garant), Renáta PITELOVÁ (203 Česká republika), Jan LOCHMAN (203 Česká republika), Vladimír MIKEŠ (203 Česká republika), Ivana DRTÍLKOVÁ (203 Česká republika) a Pavel THEINER (203 Česká republika)

Vydání

American Journal of Medical Genetics, Hoboken, NJ, Wiley-Liss, Inc. 2006, 1552-4841

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 4.463

Kód RIV

RIV/00216224:14310/06:00017436

Organizační jednotka

Přírodovědecká fakulta

UT WoS

000240877700202

Klíčová slova anglicky

ADHD; polymorphism; DAT1; DRD2; COMT; MAOB; ACE; ANG; CCR5; BDNF; MU; IL-2; IL-6; TNF; M235T

Štítky

ACE, ADHD, ANG, BDNF, CCR5, COMT, DAT1, DRD2, IL-2, IL-6, M235T, MAOB, MU, polymorphism, TNF

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 13. 2. 2008 17:31, prof. RNDr. Omar Šerý, Ph.D.

Anotace

ORIG CZ

V originále

Attention deficit hyperactivity disorder (ADHD) is a multifactorial disorder with significant genetic contribution. Dopamine genes have been the initial candidates based on the site of the action of the psychostimulant drugs. The other genes from neurotransmitter and immune system are in focus too. We have investigated whether there is an association between ADHD and polymorphisms of 13 candidate genes: DAT1, DRD2, COMT, MAOB, ACE, ANG, CCR5, BDNF, MU, IL-2, IL-6, TNF-alpha, and M235T. The aim of our case-control study was to determine whether the ADHD boys (118) have different genotype and alelic frequencies of examined polymorphisms of the above mentioned genes compared to controls (153). No significant differences were found between groups of boys in allelic and genotype frequencies of COMT, MAOB, ACE, ANG, CCR5, BDNF, MU, IL-2, IL-6, TNF-alpha and M235T genes (p < 0.05). For DAT1, the statistical analysis using Fisher exact test did not confirme the association of the previously possitive investigated 10-repeat allele or 10/10 genotype of DAT1 gene (p = 0.531). For DRD2, ADHD probands were more likely than controls to have the A1 allele and genotype A1A1 (p = 0.0013). Our results showed that ADHD in Czech children population is associated with TaqI A polymorphism of DRD2 gene. The presence of DRD2 A1 allele increases the risk of ADHD.

Česky

Při zkoumání vztahu mezi ADHD a 13-ti polymorfizmy kandidátních genů jsme objevili vztah mezi genem pro DAT1, DRD2 a ADHD.

Návaznosti

MSM0021622413, záměr

Název: Proteiny v metabolismu a při interakci organismů s prostředím

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Proteiny v metabolismu a při interakci organismů s prostředím

NR8137, projekt VaV

Název: Molekulární příčiny dispozic ke vzniku alkoholizmu.

Investor: Ministerstvo zdravotnictví ČR, Molekulární příčiny dispozic ke vzniku alkoholizmu

Citovat

ŠTAIF, Radim, Omar ŠERÝ, Renáta PITELOVÁ, Jan LOCHMAN, Vladimír MIKEŠ, Ivana DRTÍLKOVÁ a Pavel THEINER. A case-control study of the relationship between 13 candidate genes and ADHD. American Journal of Medical Genetics. Hoboken, NJ: Wiley-Liss, Inc., 2006, roč. 141B, č. 7, s. 729-730. ISSN 1552-4841.

@article{699930,
   author = {Štaif, Radim and Šerý, Omar and Pitelová, Renáta and Lochman, Jan and Mikeš, Vladimír and Drtílková, Ivana and Theiner, Pavel},
   article_location = {Hoboken, NJ},
   article_number = {7},
   keywords = {ADHD; polymorphism; DAT1; DRD2; COMT; MAOB; ACE; ANG; CCR5; BDNF; MU; IL-2; IL-6; TNF; M235T},
   language = {eng},
   issn = {1552-4841},
   journal = {American Journal of Medical Genetics},
   title = {A case-control study of the relationship between 13 candidate genes and ADHD},
   volume = {141B},
   year = {2006}
}

TY  - JOUR
ID  - 699930
AU  - Štaif, Radim - Šerý, Omar - Pitelová, Renáta - Lochman, Jan - Mikeš, Vladimír - Drtílková, Ivana - Theiner, Pavel
PY  - 2006
TI  - A case-control study of the relationship between 13 candidate genes and ADHD
JF  - American Journal of Medical Genetics
VL  - 141B
IS  - 7
SP  - 729-730
EP  - 729-730
PB  - Wiley-Liss, Inc.
SN  - 15524841
KW  - ADHD
KW  - polymorphism
KW  - DAT1
KW  - DRD2
KW  - COMT
KW  - MAOB
KW  - ACE
KW  - ANG
KW  - CCR5
KW  - BDNF
KW  - MU
KW  - IL-2
KW  - IL-6
KW  - TNF
KW  - M235T
N2  - Attention deficit hyperactivity disorder (ADHD) is a multifactorial disorder with significant genetic contribution. Dopamine genes have been the initial candidates based on the site of the action of the psychostimulant drugs. The other genes from neurotransmitter and immune system are in focus too. We have investigated whether there is an association between ADHD and polymorphisms of 13 candidate genes: DAT1, DRD2, COMT, MAOB, ACE, ANG, CCR5, BDNF, MU, IL-2, IL-6, TNF-alpha, and M235T. The aim of our case-control study was to determine whether the ADHD boys (118) have different genotype and alelic frequencies of examined polymorphisms of the above mentioned genes compared to controls (153). No significant differences were found between groups of boys in allelic and genotype frequencies of COMT, MAOB, ACE, ANG, CCR5, BDNF, MU, IL-2, IL-6, TNF-alpha and M235T genes (p < 0.05). For DAT1, the statistical analysis using Fisher exact test did not confirme the association of the previously possitive investigated 10-repeat allele or 10/10 genotype of DAT1 gene (p = 0.531). For DRD2, ADHD probands were more likely than controls to have the A1 allele and genotype A1A1 (p = 0.0013). Our results showed that ADHD in Czech children population is associated with TaqI A polymorphism of DRD2 gene. The presence of DRD2 A1 allele increases the risk of ADHD.
ER  -

ŠTAIF, Radim, Omar ŠERÝ, Renáta PITELOVÁ, Jan LOCHMAN, Vladimír MIKEŠ, Ivana DRTÍLKOVÁ a Pavel THEINER. A case-control study of the relationship between 13 candidate genes and ADHD. \textit{American Journal of Medical Genetics}. Hoboken, NJ: Wiley-Liss, Inc., 2006, roč.~141B, č.~7, s.~729-730. ISSN~1552-4841.

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