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@inproceedings{699943,
author = {Bienertová Vašků, Julie and Hlinomaz, Ota and Vašků, Anna},
address = {Hungary},
booktitle = {New Frontiers in Basic Cardiovascular Research},
keywords = {Genes; restenosis; polymerase chain reaction; leptin; polymorphism},
language = {eng},
location = {Hungary},
pages = {51-51},
publisher = {INSERM, France},
title = {Are leptin gene promoter polymorphisms associated with restenosis after coronary stenting?},
year = {2006}
}
TY - JOUR
ID - 699943
AU - Bienertová Vašků, Julie - Hlinomaz, Ota - Vašků, Anna
PY - 2006
TI - Are leptin gene promoter polymorphisms associated with restenosis after coronary stenting?
PB - INSERM, France
CY - Hungary
KW - Genes
KW - restenosis
KW - polymerase chain reaction
KW - leptin
KW - polymorphism
N2 - Background: The hypertrophy of vascular smooth muscle cells as well as neointimal proliferation is critical in vascular remodelling associated with restenosis after PCI. Leptin has recently proved to play an important role in vascular remodelling. Objectives: In this study, we investigated possible associations of two leptin gene promoter polymorphisms and restenosis after PTCA. Methods: To study possible association of two promoter polymorphisms LEP -2548 G/A and LEP-188 A/C with neointimal proliferation in humans, 98 consecutive patients undergoing stenting into small coronary arteries (<3mm) were genotyped. Restenosis was identified by quantitative coronary angiography after 6 months. Results: The restenosis > 50% occurred in 33.3% patients carrying both A alleles, 33.3% carriers of A and C alleles and 31.4% carriers of two CC alleles of LEP -188 C/A polymorphism and in 25.0% patients with AA, 32.7% with AG and 30.4% with GG genotype of LEP -2548 G/A polymorphism. Interestingly, the heterozygote AG genotype of LEP -2548 polymorphism represented a highly statistically significant risk for multiple vessel disease when compared to both homozygote genotypes AA/GG (OR=4.038, 95% CI: 1.732-9.465, p=0.0009). Conclusions: Based on our results we hypothesize that AG genotype of LEP -2548 G/A polymorphism might be considered a genetic marker for multiple vessel disease. However, the role of leptin in pathogenesis of restenosis still remains to be elucidated.
ER -
BIENERTOVÁ VAŠKŮ, Julie, Ota HLINOMAZ and Anna VAŠKŮ. Are leptin gene promoter polymorphisms associated with restenosis after coronary stenting? In \textit{New Frontiers in Basic Cardiovascular Research}. Hungary: INSERM, France, 2006, p.~51-51.
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