Are leptin gene promoter polymorphisms associated with
restenosis after coronary stenting?

D 2006

Are leptin gene promoter polymorphisms associated with restenosis after coronary stenting?

BIENERTOVÁ VAŠKŮ, Julie, Ota HLINOMAZ a Anna VAŠKŮ

Základní údaje

Originální název

Are leptin gene promoter polymorphisms associated with restenosis after coronary stenting?

Název česky

Variabilita v genu pro leptin u pacientů s restenózou po PCI

Autoři

BIENERTOVÁ VAŠKŮ, Julie (203 Česká republika, garant), Ota HLINOMAZ (203 Česká republika) a Anna VAŠKŮ (203 Česká republika)

Vydání

Hungary, New Frontiers in Basic Cardiovascular Research, od s. 51-51, 1 s. 2006

Nakladatel

INSERM, France

Další údaje

Jazyk

angličtina

Typ výsledku

Stať ve sborníku

Obor

Genetika a molekulární biologie

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Kód RIV

RIV/00216224:14110/06:00017440

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Genes; restenosis; polymerase chain reaction; leptin; polymorphism

Štítky

GENES, leptin, polymerase chain reaction, polymorphism, restenosis

Změněno: 2. 11. 2006 15:01, prof. MUDr. Julie Dobrovolná, Ph.D.

Anotace

ORIG CZ

V originále

Background: The hypertrophy of vascular smooth muscle cells as well as neointimal proliferation is critical in vascular remodelling associated with restenosis after PCI. Leptin has recently proved to play an important role in vascular remodelling. Objectives: In this study, we investigated possible associations of two leptin gene promoter polymorphisms and restenosis after PTCA. Methods: To study possible association of two promoter polymorphisms LEP -2548 G/A and LEP-188 A/C with neointimal proliferation in humans, 98 consecutive patients undergoing stenting into small coronary arteries (<3mm) were genotyped. Restenosis was identified by quantitative coronary angiography after 6 months. Results: The restenosis > 50% occurred in 33.3% patients carrying both A alleles, 33.3% carriers of A and C alleles and 31.4% carriers of two CC alleles of LEP -188 C/A polymorphism and in 25.0% patients with AA, 32.7% with AG and 30.4% with GG genotype of LEP -2548 G/A polymorphism. Interestingly, the heterozygote AG genotype of LEP -2548 polymorphism represented a highly statistically significant risk for multiple vessel disease when compared to both homozygote genotypes AA/GG (OR=4.038, 95% CI: 1.732-9.465, p=0.0009). Conclusions: Based on our results we hypothesize that AG genotype of LEP -2548 G/A polymorphism might be considered a genetic marker for multiple vessel disease. However, the role of leptin in pathogenesis of restenosis still remains to be elucidated.

Česky

Leptin se zdá být možným modulátorem v rámci neointimální proliferace, na základě našich výsledků se heterozygotní genotyp AG polymorfismu LEP-2548 G/A jeví jako slibný genetický marker pro multiple vessel disease. Úloha tohoto polymorfismu v patogenezi restenózy po PCI vyžaduje další výzkum.

Návaznosti

MSM 141100002, záměr

Název: Molekulární patofyziologie multigenních chorob

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Molekulární patofyziologie multigenních chorob

Citovat

BIENERTOVÁ VAŠKŮ, Julie, Ota HLINOMAZ a Anna VAŠKŮ. Are leptin gene promoter polymorphisms associated with restenosis after coronary stenting? In New Frontiers in Basic Cardiovascular Research. Hungary: INSERM, France, 2006, s. 51-51.

@inproceedings{699943,
   author = {Bienertová Vašků, Julie and Hlinomaz, Ota and Vašků, Anna},
   address = {Hungary},
   booktitle = {New Frontiers in Basic Cardiovascular Research},
   keywords = {Genes; restenosis; polymerase chain reaction; leptin; polymorphism},
   language = {eng},
   location = {Hungary},
   pages = {51-51},
   publisher = {INSERM, France},
   title = {Are leptin gene promoter polymorphisms associated with restenosis after coronary stenting?},
   year = {2006}
}

TY  - JOUR
ID  - 699943
AU  - Bienertová Vašků, Julie - Hlinomaz, Ota - Vašků, Anna
PY  - 2006
TI  - Are leptin gene promoter polymorphisms associated with restenosis after coronary stenting?
PB  - INSERM, France
CY  - Hungary
KW  - Genes
KW  - restenosis
KW  - polymerase chain reaction
KW  - leptin
KW  - polymorphism
N2  - Background: The hypertrophy of vascular smooth muscle cells as well as neointimal proliferation is critical in vascular remodelling associated with restenosis after PCI. Leptin has recently proved to play an important role in vascular remodelling. Objectives: In this study, we investigated possible associations of two leptin gene promoter polymorphisms and restenosis after PTCA. Methods: To study possible association of two promoter polymorphisms LEP -2548 G/A and LEP-188 A/C with neointimal proliferation in humans, 98 consecutive patients undergoing stenting into small coronary arteries (<3mm) were genotyped. Restenosis was identified by quantitative coronary angiography after 6 months. Results: The restenosis > 50% occurred in 33.3% patients carrying both A alleles, 33.3% carriers of A and C alleles and 31.4% carriers of two CC alleles of LEP -188 C/A polymorphism and in 25.0% patients with AA, 32.7% with AG and 30.4% with GG genotype of LEP -2548 G/A polymorphism. Interestingly, the heterozygote AG genotype of LEP -2548 polymorphism represented a highly statistically significant risk for multiple vessel disease when compared to both homozygote genotypes AA/GG (OR=4.038, 95% CI: 1.732-9.465, p=0.0009). Conclusions: Based on our results we hypothesize that AG genotype of LEP -2548 G/A polymorphism might be considered a genetic marker for multiple vessel disease. However, the role of leptin in pathogenesis of restenosis still remains to be elucidated.
ER  -

BIENERTOVÁ VAŠKŮ, Julie, Ota HLINOMAZ a Anna VAŠKŮ. Are leptin gene promoter polymorphisms associated with restenosis after coronary stenting? In \textit{New Frontiers in Basic Cardiovascular Research}. Hungary: INSERM, France, 2006, s.~51-51.

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