Effect of Sigma Receptor Ligand Haloperidol on Guinea Pig Isolated Heart Electrogram

NOVÁKOVÁ, Marie, Jana BARDOŇOVÁ and Ivo PROVAZNÍK. Effect of Sigma Receptor Ligand Haloperidol on Guinea Pig Isolated Heart Electrogram. In Computers in Cardiology 2006. 33rd ed. Valencia: CinC, 2006, p. 577-580. ISBN 0276-6547.

Basic information

• Original name: Effect of Sigma Receptor Ligand Haloperidol on Guinea Pig Isolated Heart Electrogram
• Name in Czech: Účinek ligandu sigma receptorů haloperidolu na elektrogram izolovaného srdce morčete
• Authors: NOVÁKOVÁ, Marie (203 Czech Republic, guarantor), Jana BARDOŇOVÁ (203 Czech Republic) and Ivo PROVAZNÍK (203 Czech Republic).
• Edition: 33. vyd. Valencia, Computers in Cardiology 2006, p. 577-580, 2006.
• Publisher: CinC

Other information

• Original language: English
• Type of outcome: Proceedings paper
• Field of Study: 30105 Physiology
• Country of publisher: Spain
• Confidentiality degree: is not subject to a state or trade secret
• RIV identification code: RIV/00216224:14110/06:00015992
• Organization unit: Faculty of Medicine
• ISBN: 0276-6547
• Keywords in English: sigma receptor;haloperidol;guinea pig isolated heart;electrogram
• Tags: electrogram, guinea pig isolated heart, haloperidol, sigma receptor

Abstract

Cardiac sigma receptors are involved in fine modulation of contractility in mammalian myocardium. Their role in the changes of cardiac excitability is studied using various experimental models. In this study, the effect of sigma receptor ligand, psychotropic drug haloperidol, was examined in isolated guinea pig hearts perfused according to Langendorff. Electrogram and coronary flow changes were followed in control and during two administrations of haloperidol. Prolongation of QT interval was found in the first, but not in the second haloperidol application. It is concluded, that sigma ligand haloperidol affects repolarization phase of cardiac electrogram and this process may explain various rhythm disturbances reported in patients treated with haloperidol.

Abstract (in Czech)

Srdeční sigma receptory se účastní jemné modulace kontraktility savčího myokardu. Jejich úloha ve změnách srdeční excitability je studována na různých experimentálních modelech. Sledovali jsme účinky ligandu sigma receptorů, psychotropní látky haloperidolu na izolované srdce morčete perfundované dle Langendorffa. Registrovali jsme elektrogram a koronární průtok v kontrole a během dvou podání haloperidolu. Pozorovali jsme prodloužení QT intervalu při první, ale ne v druhé aplikaci látky. Lze shrnout, že haloperidol ovlivňuje repolarizační fázi elektrogramu a to vysvětluje různé poruchy rytmu u pacientů léčených touto látkou.

Links

• GA102/04/0472, research and development project: Name: Optické snímání akčních potenciálů s vysokým rozlišením pro analýzu alternací T-vlny EKG signálu

Investor: Czech Science Foundation, High Resolution Optical Recording of Action Potentials for Analysis of T-wave Alternans

• GA305/04/1385, research and development project: Name: Modulační úloha sigma signalizace na elektromechanické vztahy izolovaného kardiomyocytu a srdce

Investor: Czech Science Foundation, Modulatory role of sigma signalling in electromechanical coupling of isolated cardiomyocyte and heart

• MSM0021622402, plan (intention): Name: Časná diagnostika a léčba kardiovaskulárních chorob

Investor: Ministry of Education, Youth and Sports of the CR, Early diagnostics and treatment of cardiovascular diseases