Brain metabolism and extracellular diffusion parameters after transient global hypoxia and hypoxia/ischemia in the rat

ŠLAIS, Karel, Aleš HOMOLA, Norbert ZOREMBA, Ralf KUHLEN and Eva SYKOVÁ. Brain metabolism and extracellular diffusion parameters after transient global hypoxia and hypoxia/ischemia in the rat. In Sborník abstrakt 4th International Symposium on Neuroprotection and Neurorepair. 2006.

Basic information

• Original name: Brain metabolism and extracellular diffusion parameters after transient global hypoxia and hypoxia/ischemia in the rat
• Name in Czech: Mozkový metabolismus a extracelulární difúzní parametry tranzientní globální hypoxii a hypoxii-ischemii u potkanů
• Authors: ŠLAIS, Karel (203 Czech Republic, guarantor), Aleš HOMOLA (203 Czech Republic), Norbert ZOREMBA (276 Germany), Ralf KUHLEN (276 Germany) and Eva SYKOVÁ (203 Czech Republic).
• Edition: Sborník abstrakt 4th International Symposium on Neuroprotection and Neurorepair, 2006.

Other information

• Original language: English
• Type of outcome: Conference abstract
• Field of Study: 30000 3. Medical and Health Sciences
• Country of publisher: Germany
• Confidentiality degree: is not subject to a state or trade secret
• RIV identification code: RIV/00216224:14110/06:00017757
• Organization unit: Faculty of Medicine
• Keywords in English: diffusion; ischemia; carotid occlusion; stroke
• Tags: carotid occlusion, Diffusion, ischemia, Stroke
• Tags: International impact

Abstract

In this study we investigated changes in the extracellular space parameters (volume fraction and tortuosity), as determined from concentration-time profiles of tetramethylammonium applied by iontophoresis, and the extracellular concentrations of energy-related metabolites (lactate, glucose, pyruvate) and glutamate, monitored by microdialysis, in the rat somatosensory cortex during and after transient hypoxia or hypoxia/ischemia.

Abstract (in Czech)

Práce studovala změny difúzních parametrů mozku v průběhu a po hypoxii a po jednostranné okluzi karotid se současnou hypoxiií u potkanů. Byly prokázány změny extracelulárního prostoru a tortuozity jak v průběhu, tak v postischemické fázi experimentu.

Links

• MSM0021622404, plan (intention): Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.