| KOUTNÁ, Irena, Petr KRONTORÁD, Zbyněk SVOBODA, Eva BÁRTOVÁ, Michal KOZUBEK and Stanislav KOZUBEK. New insights into gene positional clustering and its properties supported by large-scale analysis of various differentiation pathways. Genomics. United States: Elsevier Science Inc, 2007, vol. 89, No 1, p. 81-88. ISSN 0888-7543. |
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@article{705063,
author = {Koutná, Irena and Krontorád, Petr and Svoboda, Zbyněk and Bártová, Eva and Kozubek, Michal and Kozubek, Stanislav},
article_location = {United States},
article_number = {1},
keywords = {Gene clustering; Differentiation; Microarrays; HL-60; K-562},
language = {eng},
issn = {0888-7543},
journal = {Genomics},
title = {New insights into gene positional clustering and its properties supported by large-scale analysis of various differentiation pathways},
volume = {89},
year = {2007}
}
TY - JOUR
ID - 705063
AU - Koutná, Irena - Krontorád, Petr - Svoboda, Zbyněk - Bártová, Eva - Kozubek, Michal - Kozubek, Stanislav
PY - 2007
TI - New insights into gene positional clustering and its properties supported by large-scale analysis of various differentiation pathways
JF - Genomics
VL - 89
IS - 1
SP - 81-88
EP - 81-88
PB - Elsevier Science Inc
SN - 08887543
KW - Gene clustering
KW - Differentiation
KW - Microarrays
KW - HL-60
KW - K-562
N2 - To understand how genes are distributed on chromosomes we bring new insights into gene positional clustering and its properties. We have made a large-scale analysis of three types of differentiation and we observed that genes that subsequently enter into different cell processes are positionally clustered on chromosomes. Genes from the clusters are transcribed subsequently with respect to time kinetics and also to position. This means that the genes related to a cellular process are clustered together, independent of the period of time during which they are active and important for the process. Our results also demonstrate not only that there are general regions of increased or decreased levels of gene expression, but also that, in fact, in some chromosome regions we can find clustering of genes related to specific cell processes. The results provided in this paper also support the theory of transcription factories and show that transcription of genes from the clusters is managed by softer epigenetic mechanisms.
ER -
KOUTNÁ, Irena, Petr KRONTORÁD, Zbyněk SVOBODA, Eva BÁRTOVÁ, Michal KOZUBEK and Stanislav KOZUBEK. New insights into gene positional clustering and its properties supported by large-scale analysis of various differentiation pathways. \textit{Genomics}. United States: Elsevier Science Inc, 2007, vol.~89, No~1, p.~81-88. ISSN~0888-7543.
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