Three Retionoid X Receptor Gene Polymorphisms in Plaque
Psoriasis and Psoriasis Guttata

J 2007

Three Retionoid X Receptor Gene Polymorphisms in Plaque Psoriasis and Psoriasis Guttata

VAŠKŮ, Vladimír, Julie BIENERTOVÁ VAŠKŮ, Monika PÁVKOVÁ GOLDBERGOVÁ a Anna VAŠKŮ

Základní údaje

Originální název

Three Retionoid X Receptor Gene Polymorphisms in Plaque Psoriasis and Psoriasis Guttata

Název česky

Tři polymorfismy v genu pro RXR receptor u pacientů s psoriasis en plaque a psoriasis guttata

Autoři

VAŠKŮ, Vladimír (203 Česká republika, garant), Julie BIENERTOVÁ VAŠKŮ (203 Česká republika), Monika PÁVKOVÁ GOLDBERGOVÁ (203 Česká republika) a Anna VAŠKŮ (203 Česká republika)

Vydání

Dermatology, Basilej, Karger AG, 2007, 1018-8665

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30216 Dermatology and venereal diseases

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.886

Kód RIV

RIV/00216224:14110/07:00021770

Organizační jednotka

Lékařská fakulta

UT WoS

000244747600004

Klíčová slova anglicky

Retinoid X receptor gene polymorphism; psoriasis; early onset; tonsillitis; family history

Štítky

early onset, family history, psoriasis, tonsillitis

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 18. 6. 2009 08:57, prof. MUDr. Anna Vašků, CSc.

Anotace

ORIG CZ

V originále

Aim: Polymorphisms in RXRs are very interesting from the point of view of possible association of their variability with psoriasis. Methods: The total of 293 patients with plaque psoriasis, 82 patients with psoriasis guttata and 202 control subjects have been enrolled in this study focused on three polymorphisms in RXRA and RXRB genes associations. Results: A marginally significant increase in AA allelic frequency of RXRA A(39526)AA polymorphism in plaque psoriatic men compared to healthy ones was proved. In women with psoriasis guttata, the higher risk for genotypes AA and TT in RXRB 3+ 140A/T polymorphism compared to healthy women was identified ( Pcorr=0.01). The genotypes A/A and AA/AA are more frequent in plaque psoriasis patients with positive family history of psoriasis compared to the patients with negative family history of psoriasis (Pcorr=0.02). The A/A genotype is more frequent in patients with plaque psoriasis and repeated tonsillitis/tonsillectomia (P=0.02). In RXRB polymorphism, no genotype TT is observed in patients with psoriasis guttata with positive personal history of repeated tonsillitis (Pcorr=0.001). Conclusion: Individual gene characteristics of patients with psoriasis improve pharmacotherapy possibilities using pharmacogenomic approaches which could be in future further stratified according to the subtypes of psoriasis.

Česky

Individuální genové charakteristiky pacientů s psoriázou zlepšují možnosti farmakoterapie pomocí farmakogenomického přístupu. Studie hodnotí potenciál tří polymorfismů v receptoru RXR pro možný farmakogenomický zásah u pacientů s psoriasis vulgaris chronica a psoriasis guttata.

Návaznosti

MSM 141100002, záměr

Název: Molekulární patofyziologie multigenních chorob

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Molekulární patofyziologie multigenních chorob

Citovat

VAŠKŮ, Vladimír, Julie BIENERTOVÁ VAŠKŮ, Monika PÁVKOVÁ GOLDBERGOVÁ a Anna VAŠKŮ. Three Retionoid X Receptor Gene Polymorphisms in Plaque Psoriasis and Psoriasis Guttata. Dermatology. Basilej: Karger AG, 2007, roč. 02/2007, č. 214, s. 118-124. ISSN 1018-8665.

@article{705250,
   author = {Vašků, Vladimír and Bienertová Vašků, Julie and Pávková Goldbergová, Monika and Vašků, Anna},
   article_location = {Basilej},
   article_number = {214},
   keywords = {Retinoid X receptor gene polymorphism; psoriasis; early onset; tonsillitis; family history},
   language = {eng},
   issn = {1018-8665},
   journal = {Dermatology},
   title = {Three Retionoid X Receptor Gene Polymorphisms in Plaque Psoriasis and Psoriasis Guttata},
   volume = {02/2007},
   year = {2007}
}

TY  - JOUR
ID  - 705250
AU  - Vašků, Vladimír - Bienertová Vašků, Julie - Pávková Goldbergová, Monika - Vašků, Anna
PY  - 2007
TI  - Three Retionoid X Receptor Gene Polymorphisms in Plaque Psoriasis and Psoriasis Guttata
JF  - Dermatology
VL  - 02/2007
IS  - 214
SP  - 118-124
EP  - 118-124
PB  - Karger AG
SN  - 10188665
KW  - Retinoid X receptor gene polymorphism
KW  - psoriasis
KW  - early onset
KW  - tonsillitis
KW  - family history
N2  - Aim: Polymorphisms in RXRs are very interesting from the point of view of possible association of their variability with psoriasis. Methods: The total of 293 patients with plaque psoriasis, 82 patients with psoriasis guttata and 202 control subjects have been enrolled in this study focused on three polymorphisms in RXRA and RXRB genes associations. Results: A marginally significant increase in AA allelic frequency of RXRA A(39526)AA polymorphism in plaque psoriatic men compared to healthy ones was proved. In women with psoriasis guttata, the higher risk for genotypes AA and TT in RXRB 3+ 140A/T polymorphism compared to healthy women was identified ( Pcorr=0.01). The genotypes A/A and AA/AA are more frequent in plaque psoriasis patients with positive family history of psoriasis compared to the patients with negative family history of psoriasis (Pcorr=0.02). The A/A genotype is more frequent in patients with plaque psoriasis and repeated tonsillitis/tonsillectomia (P=0.02). In RXRB polymorphism, no genotype TT is observed in patients with psoriasis guttata with positive personal history of repeated tonsillitis (Pcorr=0.001). Conclusion: Individual gene characteristics of patients with psoriasis improve pharmacotherapy possibilities using pharmacogenomic approaches which could be in future further stratified according to the subtypes of psoriasis.
ER  -

VAŠKŮ, Vladimír, Julie BIENERTOVÁ VAŠKŮ, Monika PÁVKOVÁ GOLDBERGOVÁ a Anna VAŠKŮ. Three Retionoid X Receptor Gene Polymorphisms in Plaque Psoriasis and Psoriasis Guttata. \textit{Dermatology}. Basilej: Karger AG, 2007, roč.~02/2007, č.~214, s.~118-124. ISSN~1018-8665.

Podrobný výpis o publikaci