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@article{706130,
author = {Víteček, Jan and Petrlová, Jitka and Petřek, Jíří and Adam, Vojtěch and Potěšil, David and Havel, J. and Mikelová, Radka and Trnková, Libuše and Kizek, René},
article_number = {24},
keywords = {S nitrosoglutathione; nitric oxide;carbon fibre NO sensor; cyclic voltammetry},
language = {eng},
issn = {0013-4686},
journal = {Electrochim. Acta},
title = {Electrochemical study of S nitrosoglutathione and nitric oxide by carbon fibre NO sensor and cyclic voltammetry - possible way of monitoring of nitric oxide},
volume = {51},
year = {2006}
}
TY - JOUR
ID - 706130
AU - Víteček, Jan - Petrlová, Jitka - Petřek, Jíří - Adam, Vojtěch - Potěšil, David - Havel, J. - Mikelová, Radka - Trnková, Libuše - Kizek, René
PY - 2006
TI - Electrochemical study of S nitrosoglutathione and nitric oxide by carbon fibre NO sensor and cyclic voltammetry - possible way of monitoring of nitric oxide
JF - Electrochim. Acta
VL - 51
IS - 24
SP - 5087-5094
EP - 5087-5094
SN - 00134686
KW - S nitrosoglutathione
KW - nitric oxide;carbon fibre NO sensor
KW - cyclic voltammetry
N2 - Nitrosation of sulfhydryl group of glutathione, which is highly reactive and is often found conjugated to other molecules via its sulfhydryl moiety, is one of many biological effects of the nitric oxide (NO). This process may serve as a signal event and/or as a deposition of NO to S-nitrosoglutathione (GSNO). Moreover, GSNO may release NO under specific conditions. That is why NO, which has a little lifetime itself, could be distribute for longer distances within the organism. Here, we studied and compared the basic electrochemical characteristics of biological active thiol compounds (GSH, oxidized glutathione and GSNO). In addition, observation of the decomposition process of GSNO using different electrochemical techniques followed. Primarily we studied the influence of scan rate and reducing agent (Tris(2-carboxyethyl)phosphine). The CV calibration equations were linear, R.S.D. about 5%. The detection limits of GSH, GSSG and GSNO expressed as 3 S/N were 9 nM, 4 nM and 20 nM, respectively. In addition, the use of NO selective carbon fibre electrode and cyclic voltammetry for the study of GSNO decomposition catalysed by copper(II) and iron(II) followed.
ER -
VÍTEČEK, Jan, Jitka PETRLOVÁ, Jíří PETŘEK, Vojtěch ADAM, David POTĚŠIL, J. HAVEL, Radka MIKELOVÁ, Libuše TRNKOVÁ a René KIZEK. Electrochemical study of S nitrosoglutathione and nitric oxide by carbon fibre NO sensor and cyclic voltammetry - possible way of monitoring of nitric oxide. \textit{Electrochim. Acta}. 2006, roč.~51, č.~24, s.~5087-5094, 5 s. ISSN~0013-4686.
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