Limbic irritability and chaotic neural response during
conflicting Stroop task in the patients with unipolar
depression

J 2006

Limbic irritability and chaotic neural response during conflicting Stroop task in the patients with unipolar depression

BOB, Petr a Marek ŠUSTA

Základní údaje

Originální název

Limbic irritability and chaotic neural response during conflicting Stroop task in the patients with unipolar depression

Název česky

Limbická iritabilita a chaotická neuronová odezva v průběhu konfliktního Stroopova testu u pacientů s unipolární depresí

Autoři

BOB, Petr (203 Česká republika) a Marek ŠUSTA (203 Česká republika, garant)

Vydání

Physiological Research, 2006, 0862-8408

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.093

Organizační jednotka

Fakulta sociálních studií

UT WoS

000243996600012

Klíčová slova anglicky

Depression; Stress; Limbic irritability; HRV; Lyapunov exponent; Chaos; Anticonvulsants

Štítky

anticonvulsants, chaos, Depression, HRV, Limbic irritability, lyapunov exponent, stress

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 18. 12. 2006 18:53, Marek Šusta, Ph.D., MBA

Anotace

V originále

According to recent findings activation of anterior cingulate cortex (ACC) is related to detecting cognitive conflict. This conflict related activation elicits autonomic responses which can be assessed by psychophysiological measures such as heart rate variability calculated as beat to beat R-R intervals (RRI). Recent findings in neuroscience also suggest that cognitive conflict is related to specific nonlinear chaotic changes of the signal generated by neural systems. The present study used Stroop word-colour test as an experimental approach to psychophysiological study of cognitive conflict in connection with RRI measurement, psychometric measurement of limbic irritability (LSCL-33), depression (BDI-II) and calculation of largest Lyapunov exponents in nonlinear data analysis of RRI time series. Significant correlation 0.61 between largest Lyapunov exponents and LSCL-33 found in this study indicate that a defect of neural inhibition during conflicting Stroop task is closely related to limbic irritability. Because limbic irritability is probably closely related to epileptiform abnormalities in the temporo-limbic structures, this result might represent useful instrument for indication of anticonvulsant treatment in depressive patients who are resistant to antidepressant medication.

Návaznosti

1M06039, projekt VaV

Název: Centrum pro neuropsychiatrický výzkum traumatického stresu

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Centrum pro neuropsychiatrická studia traumatického stresu - NEURPSYCHTS

Citovat

BOB, Petr a Marek ŠUSTA. Limbic irritability and chaotic neural response during conflicting Stroop task in the patients with unipolar depression. Physiological Research. 2006, roč. 55, č. 1. ISSN 0862-8408.

@article{706195,
   author = {Bob, Petr and Šusta, Marek},
   article_number = {1},
   keywords = {Depression; Stress; Limbic irritability; HRV; Lyapunov exponent; Chaos; Anticonvulsants},
   language = {eng},
   issn = {0862-8408},
   journal = {Physiological Research},
   title = {Limbic irritability and chaotic neural response during conflicting Stroop task in the patients with unipolar depression},
   volume = {55},
   year = {2006}
}

TY  - JOUR
ID  - 706195
AU  - Bob, Petr - Šusta, Marek
PY  - 2006
TI  - Limbic irritability and chaotic neural response during conflicting Stroop task in the patients with unipolar depression
JF  - Physiological Research
VL  - 55
IS  - 1
SN  - 08628408
KW  - Depression
KW  - Stress
KW  - Limbic irritability
KW  - HRV
KW  - Lyapunov exponent
KW  - Chaos
KW  - Anticonvulsants
N2  - According to recent findings activation of anterior cingulate cortex (ACC) is related to detecting cognitive conflict. This conflict related activation elicits autonomic responses which can be assessed by psychophysiological measures such as heart rate variability calculated as beat to beat R-R intervals (RRI). Recent findings in neuroscience also suggest that cognitive conflict is related to specific nonlinear chaotic changes of the signal generated by neural systems. The present study used Stroop word-colour test as an experimental approach to psychophysiological study of cognitive conflict in connection with RRI measurement, psychometric measurement of limbic irritability (LSCL-33), depression (BDI-II) and calculation of largest Lyapunov exponents in nonlinear data analysis of RRI time series. Significant correlation 0.61 between largest Lyapunov exponents and LSCL-33 found in this study indicate that a defect of neural inhibition during conflicting Stroop task is closely related to limbic irritability. Because limbic irritability is probably closely related to epileptiform abnormalities in the temporo-limbic structures, this result might represent useful instrument for indication of anticonvulsant treatment in depressive patients who are resistant to antidepressant medication.
ER  -

BOB, Petr a Marek ŠUSTA. Limbic irritability and chaotic neural response during conflicting Stroop task in the patients with unipolar depression. \textit{Physiological Research}. 2006, roč.~55, č.~1. ISSN~0862-8408.

Podrobný výpis o publikaci