2007
Prefrontal but not temporal gray matter changes in males with first-episode schizophrenia
KAŠPÁREK, Tomáš, Radovan PŘIKRYL, Michal MIKL, Daniel SCHWARZ, Eva ČEŠKOVÁ et. al.Základní údaje
Originální název
Prefrontal but not temporal gray matter changes in males with first-episode schizophrenia
Název česky
Prefrontální, ne však temporální, změny šedé hmoty u mužů s první epizodou schizofrenie
Název anglicky
Prefrontal but not temporal gray matter changes in males with first-episode schizophrenia
Autoři
KAŠPÁREK, Tomáš (203 Česká republika, garant), Radovan PŘIKRYL (203 Česká republika), Michal MIKL (203 Česká republika), Daniel SCHWARZ (203 Česká republika), Eva ČEŠKOVÁ (203 Česká republika) a Petr KRUPA (203 Česká republika)
Vydání
Progress in Neuro-Psychopharmacology and Biological Psychiatry, Elsevier, 2007, 0278-5846
Další údaje
Jazyk
čeština
Typ výsledku
Článek v odborném periodiku
Obor
30000 3. Medical and Health Sciences
Stát vydavatele
Česká republika
Utajení
není předmětem státního či obchodního tajemství
Odkazy
Impakt faktor
Impact factor: 2.802
Kód RIV
RIV/00216224:14110/07:00021809
Organizační jednotka
Lékařská fakulta
UT WoS
000243738000021
Klíčová slova anglicky
first-episode; optimized voxel-based morphometry; prefrontal cortex; schizophrenia
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 19. 6. 2009 14:15, prof. MUDr. Eva Češková, CSc.
V originále
Objectives of the study was to investigate regional gray matter changes in the first-episode schizophrenia patients. We used optimized voxel-based morphometry in 22 first-episode schizophrenia patients and 18 healthy controls of comparable age, gender and handedness. The first episode group had significantly reduced gray matter volume in the prefrontal cortex (inferior and middle prefrontal gyrus, cingulate gyrus). We identified no differences in temporal cortex. Our data support the theoretical assumption that prefrontal dysfunction underlines the primary pathology and clinical manifestation of schizophrenia. We are inclined to explain the differences in the pattern of morphological changes reported in other first-episode studies - especially the lack of changes in the temporal cortex - by heterogenity of schizophrenia, potential progression and antipsychotic medication effect.
Anglicky
Objectives of the study was to investigate regional gray matter changes in the first-episode schizophrenia patients. We used optimized voxel-based morphometry in 22 first-episode schizophrenia patients and 18 healthy controls of comparable age, gender and handedness. The first episode group had significantly reduced gray matter volume in the prefrontal cortex (inferior and middle prefrontal gyrus, cingulate gyrus). We identified no differences in temporal cortex. Our data support the theoretical assumption that prefrontal dysfunction underlines the primary pathology and clinical manifestation of schizophrenia. We are inclined to explain the differences in the pattern of morphological changes reported in other first-episode studies - especially the lack of changes in the temporal cortex - by heterogenity of schizophrenia, potential progression and antipsychotic medication effect.
Návaznosti
| MSM0021622404, záměr |
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