| KAŠPÁREK, Tomáš, Radovan PŘIKRYL, Michal MIKL, Daniel SCHWARZ, Eva ČEŠKOVÁ a Petr KRUPA. Prefrontal but not temporal gray matter changes in males with first-episode schizophrenia. Progress in Neuro-Psychopharmacology and Biological Psychiatry. Elsevier, 2007, roč. 2007, č. 31, s. 151-157. ISSN 0278-5846. |
Další formáty:
BibTeX
LaTeX
RIS
@article{707161,
author = {Kašpárek, Tomáš and Přikryl, Radovan and Mikl, Michal and Schwarz, Daniel and Češková, Eva and Krupa, Petr},
article_number = {31},
keywords = {first-episode; optimized voxel-based morphometry; prefrontal cortex; schizophrenia},
language = {cze},
issn = {0278-5846},
journal = {Progress in Neuro-Psychopharmacology and Biological Psychiatry},
title = {Prefrontal but not temporal gray matter changes in males with first-episode schizophrenia},
url = {http://dx.doi.org/10.1016/j.pnpbp.2006.08.011},
volume = {2007},
year = {2007}
}
TY - JOUR
ID - 707161
AU - Kašpárek, Tomáš - Přikryl, Radovan - Mikl, Michal - Schwarz, Daniel - Češková, Eva - Krupa, Petr
PY - 2007
TI - Prefrontal but not temporal gray matter changes in males with first-episode schizophrenia
JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry
VL - 2007
IS - 31
SP - 151-157
EP - 151-157
PB - Elsevier
SN - 02785846
KW - first-episode
KW - optimized voxel-based morphometry
KW - prefrontal cortex
KW - schizophrenia
UR - http://dx.doi.org/10.1016/j.pnpbp.2006.08.011
N2 - Objectives of the study was to investigate regional gray matter changes in the first-episode schizophrenia patients. We used optimized voxel-based morphometry in 22 first-episode schizophrenia patients and 18 healthy controls of comparable age, gender and handedness. The first episode group had significantly reduced gray matter volume in the prefrontal cortex (inferior and middle prefrontal gyrus, cingulate gyrus). We identified no differences in temporal cortex. Our data support the theoretical assumption that prefrontal dysfunction underlines the primary pathology and clinical manifestation of schizophrenia. We are inclined to explain the differences in the pattern of morphological changes reported in other first-episode studies - especially the lack of changes in the temporal cortex - by heterogenity of schizophrenia, potential progression and antipsychotic medication effect.
ER -
KAŠPÁREK, Tomáš, Radovan PŘIKRYL, Michal MIKL, Daniel SCHWARZ, Eva ČEŠKOVÁ a Petr KRUPA. Prefrontal but not temporal gray matter changes in males with first-episode schizophrenia. \textit{Progress in Neuro-Psychopharmacology and Biological Psychiatry}. Elsevier, 2007, roč.~2007, č.~31, s.~151-157. ISSN~0278-5846.
|
