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@inproceedings{709035, author = {Grochová, Diana and Vaňková, Jana and Ravčuková, Barbora and Svitáková, Miluše and Šmardová, Jana}, address = {Brno}, booktitle = {X. pracovní setkání biochemiků a molekulárních biologů}, keywords = {p53; FASAY; transactivation; tumor; conformation}, language = {eng}, location = {Brno}, isbn = {80-210-3942-6}, pages = {24-25}, publisher = {Masarykova univerzita}, title = {Analysis of temperature sensitive p53 mutants}, year = {2006} }
TY - JOUR ID - 709035 AU - Grochová, Diana - Vaňková, Jana - Ravčuková, Barbora - Svitáková, Miluše - Šmardová, Jana PY - 2006 TI - Analysis of temperature sensitive p53 mutants PB - Masarykova univerzita CY - Brno SN - 8021039426 KW - p53 KW - FASAY KW - transactivation KW - tumor KW - conformation N2 - Mutations of the p53 gene have been found in over half all human cancers. There are several techniques available for detection of p53 mutaations including FASAY (functional analysis of separated alleles in yeast). We analyzed the p53 status in various human tumors by FASAY, including acute myeloid leukemia, myelodysplatic syndrome, malignant melanoma, head and neck squamous cell carcinoma, breast and ovarian cancer, leimyosarcoma and chronic lymphoid leukemia. We identified 22 temperature-sensitive p53 mutations and localized most of them to the part of the gene coding for DNA-binding domain. Functional outomes of individual mutations were addressed. Deatailoed analysis and stratification fo p53 mutants coubd be helpful for better understanding of the effects of specific turmorogenic mutations and for therapy designed to restore function of the p53 protein. ER -
GROCHOVÁ, Diana, Jana VAŇKOVÁ, Barbora RAVČUKOVÁ, Miluše SVITÁKOVÁ a Jana ŠMARDOVÁ. Analysis of temperature sensitive p53 mutants. In \textit{X. pracovní setkání biochemiků a molekulárních biologů}. Brno: Masarykova univerzita, 2006, s.~24-25. ISBN~80-210-3942-6.
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