OBERSTRASS, Florian, Albert LEE, Richard ŠTEFL, Michael JANIS, Guillaume CHANFREAU a Frederic ALLAIN. Shape-specific recognition in the structure of the Vts1p SAM domain with RNA. NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2006, roč. 13, č. 2, s. 160-167. ISSN 1545-9985.
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Základní údaje
Originální název Shape-specific recognition in the structure of the Vts1p SAM domain with RNA
Název česky Shape-specific recognition in the structure of the Vts1p SAM domain with RNA
Autoři OBERSTRASS, Florian (756 Švýcarsko), Albert LEE (840 Spojené státy), Richard ŠTEFL (203 Česká republika, garant), Michael JANIS (840 Spojené státy), Guillaume CHANFREAU (250 Francie) a Frederic ALLAIN (250 Francie).
Vydání NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2006, 1545-9985.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor 10600 1.6 Biological sciences
Stát vydavatele Spojené státy
Utajení není předmětem státního či obchodního tajemství
Impakt faktor Impact factor: 11.502
Kód RIV RIV/00216224:14310/06:00018474
Organizační jednotka Přírodovědecká fakulta
UT WoS 000235160500015
Klíčová slova anglicky SACCHAROMYCES-CEREVISIAE; REPRESSES TRANSLATION; DEADENYLASE COMPLEX; DROSOPHILA EMBRYO; DIPOLAR COUPLINGS; CRYSTAL-STRUCTURE; CCR4-NOT COMPLEX; GENE-EXPRESSION
Štítky CCR4-NOT COMPLEX, CRYSTAL-STRUCTURE, DEADENYLASE COMPLEX, DIPOLAR COUPLINGS, DROSOPHILA EMBRYO, GENE-EXPRESSION, REPRESSES TRANSLATION, SACCHAROMYCES-CEREVISIAE
Příznaky Mezinárodní význam, Recenzováno
Změnil Změnil: prof. Mgr. Richard Štefl, Ph.D., učo 19362. Změněno: 22. 2. 2007 13:16.
Anotace
Although the abundant sterile alpha motif (SAM) domain was originally classified as a protein-protein interaction domain, it has recently been shown that certain SAM domains have the ability to bind RNA, defining a new type of post-transcriptional gene regulator. To further understand the function of SAM-RNA recognition, we determined the solution structures of the SAM domain of the Saccharomyces cerevisiae Vts1p (Vts1p-SAM) and the Smaug response element (SRE) stem-loop RNA as a complex and in isolation. The structures show that Vts1p-SAM recognizes predominantly the shape of the SRE rather than its sequence, with the exception of a G located at the tip of the pentaloop. Using microarray gene profiling, we identified several genes in S. cerevisiae that seem to be regulated by Vts1p and contain one or more copies of the SRE.
Anotace česky
Although the abundant sterile alpha motif (SAM) domain was originally classified as a protein-protein interaction domain, it has recently been shown that certain SAM domains have the ability to bind RNA, defining a new type of post-transcriptional gene regulator. To further understand the function of SAM-RNA recognition, we determined the solution structures of the SAM domain of the Saccharomyces cerevisiae Vts1p (Vts1p-SAM) and the Smaug response element (SRE) stem-loop RNA as a complex and in isolation. The structures show that Vts1p-SAM recognizes predominantly the shape of the SRE rather than its sequence, with the exception of a G located at the tip of the pentaloop. Using microarray gene profiling, we identified several genes in S. cerevisiae that seem to be regulated by Vts1p and contain one or more copies of the SRE.
Návaznosti
MSM0021622413, záměrNázev: Proteiny v metabolismu a při interakci organismů s prostředím
Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Proteiny v metabolismu a při interakci organismů s prostředím
VytisknoutZobrazeno: 10. 5. 2024 05:37