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@article{710928,
author = {Vyzula, Rostislav and Kocáková, Ilona and Demlová, Regina and Kiss, Igor and Dušek, Ladislav and Jarkovský, Jiří},
article_number = {2},
keywords = {colorectal cancer; palliative chemotherapy; raltitrexed oxaliplatin},
language = {eng},
issn = {0028-2685},
journal = {Neoplasma},
title = {Raltitrexed plus oxaliplatin in the second-line treatment of metastatic colorectal cancer.},
volume = {53},
year = {2006}
}
TY - JOUR
ID - 710928
AU - Vyzula, Rostislav - Kocáková, Ilona - Demlová, Regina - Kiss, Igor - Dušek, Ladislav - Jarkovský, Jiří
PY - 2006
TI - Raltitrexed plus oxaliplatin in the second-line treatment of metastatic colorectal cancer.
JF - Neoplasma
VL - 53
IS - 2
SP - 119-127
EP - 119-127
SN - 00282685
KW - colorectal cancer
KW - palliative chemotherapy
KW - raltitrexed oxaliplatin
N2 - The primary endpoint of this study was to evaluate the efficacy (objective response rate; ORR) of combined chemotherapy with raltitrexed plus oxaliplatin as second-line treatment in patients with metastatic colorectal cancer (CRC). Secondary endpoints were overall survival (OS), time to progression (TTP) and toxicity (NCI-CTC criteria). The target population were patients with metastatic colorectal adenocarcinoma who progressed after first-line chemotherapy. Treatment consisted of raltitrexed 3 mg/m(2) as a 15-minute intravenous (IV) infusion followed 45 minutes later by oxaliplatin 130 mg/m(2) IV as a 2-h infusion on Day 1, repeated every 3 weeks until further disease progression (PD), unacceptable toxicity or the decision of the patient. A total of 51 patients, all with WHO performance status 0-2 received a median of 6 treatment cycles (range 1-11). After 3 cycles, 8 of the 47 evaluable patients (17%) had experienced an ORR, 28 patients (59.6%) had experienced stable disease (SD) and 11 patients (23.4%) had PD. After 6 cycles, 1 of the 29 evaluable patients (3.5%) had an ORR, 13 patients (44.8%) had SD and 15 patients (51.7%) had PD. After a median follow-up of 48.9 weeks, median TTP was 18 weeks and median overall survival was 54.4 weeks. Treatment was well tolerated; grade 3 toxicities occurred in only 5/51 patients (9.8%). The most common toxicities were paraesthesia (62.7%), diarrhoea (23.5%), nausea (41.2%), vomiting (33.3%), hepatotoxicity (25.5%), and hematological toxicity (41.2%). In conclusion, the combination of oxaliplatin plus raltitrexed appears to be effective and well tolerated as second-line therapy in patients with disseminated CRC.
ER -
VYZULA, Rostislav, Ilona KOCÁKOVÁ, Regina DEMLOVÁ, Igor KISS, Ladislav DUŠEK a Jiří JARKOVSKÝ. Raltitrexed plus oxaliplatin in the second-line treatment of metastatic colorectal cancer. \textit{Neoplasma}. 2006, roč.~53, č.~2, s.~119-127. ISSN~0028-2685.
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