Effect of ajmaline on course of action potential and ionic membrane currents in rat ventricular myocytes

BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Michal PÁSEK, Milena ŠIMURDOVÁ and Jiří ŠIMURDA. Effect of ajmaline on course of action potential and ionic membrane currents in rat ventricular myocytes. In Scripta Medica. 2005. ISSN 1211-3395.

Basic information

• Original name: Effect of ajmaline on course of action potential and ionic membrane currents in rat ventricular myocytes
• Name in Czech: Vliv ajmalinu na akční napětí a iontové membránové proudy u komorových srdečních buněk potkana
• Authors: BÉBAROVÁ, Markéta (203 Czech Republic, guarantor, belonging to the institution), Peter MATEJOVIČ (703 Slovakia, belonging to the institution), Michal PÁSEK (203 Czech Republic, belonging to the institution), Milena ŠIMURDOVÁ (203 Czech Republic, belonging to the institution) and Jiří ŠIMURDA (203 Czech Republic, belonging to the institution).
• Edition: Scripta Medica, 2005.

Other information

• Original language: English
• Type of outcome: Conference abstract
• Field of Study: 30105 Physiology
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• RIV identification code: RIV/00216224:14110/05:00021928
• Organization unit: Faculty of Medicine
• ISSN: 1211-3395
• Keywords in English: ajmaline;action potential;ionic currents;rat;patch clamp
• Tags: Action potential, ajmaline, ionic currents, patch clamp, rat
• Tags: International impact

Abstract

Ajmaline decreased the upstroke velocity of action potential and its amplitude, very likely by inhibition of sodium current INa. The observed prolongation of action potential was probably related to the inhibition of transient outward potassium current Ito, the main repolarizing current in rat. This effect predominates over the opposite effect of the inhibition of calcium current ICaL, partly because of lower IC50.

Abstract (in Czech)

Ajmalie zpomaloval depolarizační fázi akčního napětí a snižoval jeho amplitudu, velice pravděpodobně díky inhibici sodíkového proudu. Prodloužení trvání akčního napětí bylo zase nejspíš důsledkem blokády přechodného draslíkového proudu z buňky, hlavního repolarizačního proudu u potkana. Tento efekt převládl nad opačným efektem způsobeným blokádou vápníkového proudu, zejména vzhledem k nižší IC50.

Links

• MSM0021622402, plan (intention): Name: Časná diagnostika a léčba kardiovaskulárních chorob

Investor: Ministry of Education, Youth and Sports of the CR, Early diagnostics and treatment of cardiovascular diseases