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@article{713129,
author = {Juřica, Jan and Dostálek, Miroslav and Konečný, Jiří and Glatz, Zdeněk and Hadašová, Eva and Tomandl, Josef},
article_location = {Amsterdam, The Netherlands},
article_number = {1-2},
keywords = {cytochrome P450; midazolam; 1'-hydroxymidazolam; 4-hydroxymidazolam; 1'4-dihydroxymidazolam; rat; perfusion; plasma; HPLC},
language = {eng},
issn = {1570-0232},
journal = {Journal of Chromatography B},
note = {doi:10.1016/j.jchromb.2007.02.034},
title = {HPLC determination of midazolam and its three hydroxy metabolites in perfusion medium and plasma from rats},
url = {http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6X0P-4N4J320-4&_user=835458&_coverDate=06%2F01%2F2007&_alid=584152625&_rdoc=1&_fmt=summary&_orig=search&_cdi=7220&_sort=d&_st=4&_docanchor=&_ct=44&_acct=C000045159&_version=1&_urlVersion=0&_userid},
volume = {852},
year = {2007}
}
TY - JOUR
ID - 713129
AU - Juřica, Jan - Dostálek, Miroslav - Konečný, Jiří - Glatz, Zdeněk - Hadašová, Eva - Tomandl, Josef
PY - 2007
TI - HPLC determination of midazolam and its three hydroxy metabolites in perfusion medium and plasma from rats
JF - Journal of Chromatography B
VL - 852
IS - 1-2
SP - 571-577
EP - 571-577
PB - Elsevier
SN - 15700232
N1 - doi:10.1016/j.jchromb.2007.02.034
KW - cytochrome P450
KW - midazolam
KW - 1'-hydroxymidazolam
KW - 4-hydroxymidazolam
KW - 1'4-dihydroxymidazolam
KW - rat
KW - perfusion
KW - plasma
KW - HPLC
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6X0P-4N4J320-4&_user=835458&_coverDate=06%2F01%2F2007&_alid=584152625&_rdoc=1&_fmt=summary&_orig=search&_cdi=7220&_sort=d&_st=4&_docanchor=&_ct=44&_acct=C000045159&_version=1&_urlVersion=0&_userid
N2 - A new, simple, rapid, sensitive, and repeatable isocratic reverse-phase HPLC method was developed and validated for simultaneous determination of midazolam and its main three hydroxylated metabolites, i.e. 1' hydroxymidazolam, 4-hydroxymidazolam, and 1',4-dihydroxymidazolam in rat liver perfusate and also plasma. Diazepam was used as an internal standard to ensure precision and accuracy of this method. This method is applicable for modeling and description of possible pharmacological interactions on rat (CYP3A1/2) or human (CYP3A4/5) cytochrome P450 enzymes.
ER -
JUŘICA, Jan, Miroslav DOSTÁLEK, Jiří KONEČNÝ, Zdeněk GLATZ, Eva HADAŠOVÁ a Josef TOMANDL. HPLC determination of midazolam and its three hydroxy metabolites in perfusion medium and plasma from rats. \textit{Journal of Chromatography B}. Amsterdam, The Netherlands: Elsevier, 2007, roč.~852, 1-2, s.~571-577. ISSN~1570-0232.
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