| BARTOŠ, Tomáš, Štefan LETZSCH, Michal ŠKAREK, Zuzana FLEGROVÁ, Pavel ČUPR a Ivan HOLOUBEK. GFP assay as a sensitive eukaryotic screening model to detect toxic and genotoxic activity of azaarenes. Environmental Toxicology. USA, 2006, roč. 21, č. 1, s. 343-348. ISSN 1520-4081. |
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@article{715508,
author = {Bartoš, Tomáš and Letzsch, Štefan and Škarek, Michal and Flegrová, Zuzana and Čupr, Pavel and Holoubek, Ivan},
article_location = {USA},
article_number = {1},
keywords = {azaarenes; GFP yeast bioassay; genotoxicity; toxicity},
language = {eng},
issn = {1520-4081},
journal = {Environmental Toxicology},
title = {GFP assay as a sensitive eukaryotic screening model to detect toxic and genotoxic activity of azaarenes.},
volume = {21},
year = {2006}
}
TY - JOUR
ID - 715508
AU - Bartoš, Tomáš - Letzsch, Štefan - Škarek, Michal - Flegrová, Zuzana - Čupr, Pavel - Holoubek, Ivan
PY - 2006
TI - GFP assay as a sensitive eukaryotic screening model to detect toxic and genotoxic activity of azaarenes.
JF - Environmental Toxicology
VL - 21
IS - 1
SP - 343-348
EP - 343-348
SN - 15204081
KW - azaarenes
KW - GFP yeast bioassay
KW - genotoxicity
KW - toxicity
N2 - Azaarenes are nitrogen-containing polyaromatic heterocyclic compounds (NPAHs). The majority of the azaarenes found in the environment originate from anthropogenic sources. Concentrations of NPAHs found in the environment are reported to be one to two orders of magnitude lower than polycyclic aromatic hydrocarbons (PAHs) concentrations, yet their biological effects can be of similar magnitude.Azaarenes are nitrogen-containing polyaromatic heterocyclic compounds (NPAHs). The majority of the azaarenes found in the environment originate from anthropogenic sources. Concentrations of NPAHs found in the environment are reported to be one to two orders of magnitude lower than polycyclic aromatic hydrocarbons (PAHs) concentrations, yet their biological effects can be of similar magnitude. To assess the toxic and genotoxic activity, a green fluorescent protein (GFP) assay based on the yeast Saccharomyces cerevisiae was selected. In this study, the authors present evidence that genotoxicity assessment using the yeast GFP assay can provide a simple system to monitor the activity of these environmental pollutants that could possess mutagenic potential at low concentrations.
ER -
BARTOŠ, Tomáš, Štefan LETZSCH, Michal ŠKAREK, Zuzana FLEGROVÁ, Pavel ČUPR a Ivan HOLOUBEK. GFP assay as a sensitive eukaryotic screening model to detect toxic and genotoxic activity of azaarenes. \textit{Environmental Toxicology}. USA, 2006, roč.~21, č.~1, s.~343-348. ISSN~1520-4081.
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