KALA, Zdeněk, Jiří DOLINA, Filip MAREK and Lydie IZAKOVIČOVÁ HOLLÁ. Polymorphisms of glutathione S-transferase (GST) M1, T1, and P1 in patients with reflux esophagitis and Barretts esophagus. J Hum Genet. Springer, 2007, vol. 52, No 6, p. 527-534. ISSN 1434-5161.
Other formats:   BibTeX LaTeX RIS
Basic information
Original name Polymorphisms of glutathione S-transferase (GST) M1, T1, and P1 in patients with reflux esophagitis and Barretts esophagus
Name in Czech Polymorfizmy v genech pro glutathion S-transferázu (GST) M1, T1 a P1 u pacientů s refluxní esofagitidou a Baretovým jícnem
Authors KALA, Zdeněk (203 Czech Republic), Jiří DOLINA (203 Czech Republic), Filip MAREK (203 Czech Republic) and Lydie IZAKOVIČOVÁ HOLLÁ (203 Czech Republic, guarantor).
Edition J Hum Genet, Springer, 2007, 1434-5161.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30200 3.2 Clinical medicine
Country of publisher Japan
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 2.275
RIV identification code RIV/00216224:14110/07:00020198
Organization unit Faculty of Medicine
UT WoS 000247157100009
Keywords in English GERD; GSTs; glutathione S-transferase; polymorphism; reflux esophagitis; gene; Barretts esophagus
Tags Barretts esophagus, gene, GERD, glutathione S-transferase, GSTs, polymorphism, reflux esophagitis
Tags International impact, Reviewed
Changed by Changed by: prof. MUDr. Lydie Izakovičová Hollá, Ph.D., učo 734. Changed: 17/6/2009 11:23.
Abstract
Reflux esophagitis (RE) and Barretts esophagus belong to the most common esophageal complications of gastroesophageal reflux disease. Glutathione S-transferase (GST) enzymes play an important role in cellular protection against oxidative stress and toxic foreign chemicals. Therefore, we investigated the hypothesis that polymorphisms in genes for these detoxifying enzymes could influence susceptibility to RE and Barretts esophagus.
Abstract (in Czech)
Refluxní esofagitida (RE) a Baretův jícen patří k nejběžnějším komplikacím GERD. Enzymy glutathion S-transferázy (GST) hrají důležitou úlohu v ochraně buněk proti oxidačnímu stresu a toxickým látkám. V práci jsme zkoumali, zda polymorfizmy v genech pro tyto detoxifikační enzymy mohou ovlivňovat náchylnost k rozvoji RE a Baretova jícnu.
Links
GA310/06/0827, research and development projectName: Genetické determinanty pro-/antioxidační rovnováhy v patogeneze respiračních nemocí
Investor: Czech Science Foundation
2B06060, research and development projectName: Zefektivnění diagnostiky a léčby gastroezofageální refluxní choroby jícnu (Acronym: NPVII11002)
Investor: Ministry of Education, Youth and Sports of the CR
PrintDisplayed: 30/4/2024 16:06