Activity-dependent changes of [Ca2+] in the transverse-axial tubular system reduce SR Ca2+ content and Ca2+ transient amplitude in rat and guinea pig cardiac ventricular myocytes: a simulation study

PÁSEK, Michal; Jiří ŠIMURDA; Clive ORCHARD and Georges CHRISTÉ. Activity-dependent changes of [Ca2+] in the transverse-axial tubular system reduce SR Ca2+ content and Ca2+ transient amplitude in rat and guinea pig cardiac ventricular myocytes: a simulation study. In Main Meeting of the Physiological Society (London). 2006.

Basic information

Original name

Activity-dependent changes of [Ca2+] in the transverse-axial tubular system reduce SR Ca2+ content and Ca2+ transient amplitude in rat and guinea pig cardiac ventricular myocytes: a simulation study

Name in Czech

Aktivitou-podmíněné změny [Ca2+] v transverzálně-axiálním tubulárním systému redukují obsah Ca2+ v SR a snižují amplitudu přechodných změn Ca2+ v cytoplazmě v modelu komorové srdeční buňky potkana a morčete

Authors

PÁSEK, Michal (203 Czech Republic, guarantor); Jiří ŠIMURDA (203 Czech Republic); Clive ORCHARD (826 United Kingdom of Great Britain and Northern Ireland) and Georges CHRISTÉ (250 France)

Edition

Main Meeting of the Physiological Society (London), 2006

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Other information

Language

English

Type of outcome

Conference abstract

Field of Study

10610 Biophysics

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

is not subject to a state or trade secret

RIV identification code

RIV/00216224:14110/06:00015543

Organization unit

Faculty of Medicine

Keywords in English

cardiac cell; T-tubule; quantitative modelling

Tags

Cardiac cell, Quantitative modelling, T-tubule

Tags

International impact, Reviewed

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Abstract

In the original language

To explore the physiological consequences of ion concentration changes in the transverse-axial tubular system (TATS) of rat and guinea-pig cardiac ventricular myocytes, we have developed mathematical models of their electrical activity that include a quantitative description of the TATS. In both models, transient depletion of tubular Ca2+ occurred during each action potential and decreased intracellular Ca2+ load and consequently systolic Ca2+ transient amplitude. However, the magnitude of this effect and its frequency dependence was different in the two species.

In Czech

Práce popisuje výsledky vyšetření fyziologických důsledků iontově koncentračních změn v transverzálně–axiálním tubulárním systému u komorových srdečních buněk potkana a morčete. Vyšetření je provedeno na matematických modelech.

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Links

AV0Z20760514, plan (intention)	Name: Komplexní dynamické systémy v termodynamice, mechanice tekutin a těles
MSM0021622402, plan (intention)	Name: Časná diagnostika a léčba kardiovaskulárních chorob Investor: Ministry of Education, Youth and Sports of the CR, Early diagnostics and treatment of cardiovascular diseases