Další formáty:
BibTeX
LaTeX
RIS
@proceedings{717071,
author = {Pásek, Michal and Šimurda, Jiří and Orchard, Clive and Christé, Georges},
booktitle = {Main Meeting of the Physiological Society (London)},
keywords = {cardiac cell; T-tubule; quantitative modelling},
language = {eng},
title = {Activity-dependent changes of [Ca2+] in the transverse-axial tubular system reduce SR Ca2+ content and Ca2+ transient amplitude in rat and guinea pig cardiac ventricular myocytes: a simulation study},
year = {2006}
}
TY - CONF
ID - 717071
AU - Pásek, Michal - Šimurda, Jiří - Orchard, Clive - Christé, Georges
PY - 2006
TI - Activity-dependent changes of [Ca2+] in the transverse-axial tubular system reduce SR Ca2+ content and Ca2+ transient amplitude in rat and guinea pig cardiac ventricular myocytes: a simulation study
KW - cardiac cell
KW - T-tubule
KW - quantitative modelling
N2 - To explore the physiological consequences of ion concentration changes in the transverse-axial tubular system (TATS) of rat and guinea-pig cardiac ventricular myocytes, we have developed mathematical models of their electrical activity that include a quantitative description of the TATS. In both models, transient depletion of tubular Ca2+ occurred during each action potential and decreased intracellular Ca2+ load and consequently systolic Ca2+ transient amplitude. However, the magnitude of this effect and its frequency dependence was different in the two species.
ER -
PÁSEK, Michal, Jiří ŠIMURDA, Clive ORCHARD a Georges CHRISTÉ. Activity-dependent changes of [Ca2+] in the transverse-axial tubular system reduce SR Ca2+ content and Ca2+ transient amplitude in rat and guinea pig cardiac ventricular myocytes: a simulation study. In \textit{Main Meeting of the Physiological Society (London)}. 2006.
|
