| ZHANG, Jie, Jiří KONEČNÝ, Zdeněk GLATZ, Jos HOOGMARTENS a Ann VAN SCHEPDAEL. Review: Application of capillary electrophoresis in drug metabolism studies. Current Analytical Chemistry. USA: BENTHAM SCIENCE PUBL LTD, 2007, roč. 3, č. 3, s. 197-217. ISSN 1573-4110. |
Další formáty:
BibTeX
LaTeX
RIS
@article{719245,
author = {Zhang, Jie and Konečný, Jiří and Glatz, Zdeněk and Hoogmartens, Jos and Van Schepdael, Ann},
article_location = {USA},
article_number = {3},
keywords = {capillary electrophoresis; drug metabolism},
language = {eng},
issn = {1573-4110},
journal = {Current Analytical Chemistry},
title = {Review: Application of capillary electrophoresis in drug metabolism studies},
volume = {3},
year = {2007}
}
TY - JOUR
ID - 719245
AU - Zhang, Jie - Konečný, Jiří - Glatz, Zdeněk - Hoogmartens, Jos - Van Schepdael, Ann
PY - 2007
TI - Review: Application of capillary electrophoresis in drug metabolism studies
JF - Current Analytical Chemistry
VL - 3
IS - 3
SP - 197-217
EP - 197-217
PB - BENTHAM SCIENCE PUBL LTD
SN - 15734110
KW - capillary electrophoresis
KW - drug metabolism
N2 - Capillary electrophoresis (CE) has been increasingly employed for the separation of pharmaceutical agents and drugs. This has arisen from the complementary mode of separation afforded by CE when compared to high performance liquid chromatography (HPLC). Qualities of CE such as high efficiency of separation, short analysis time, remarkably low injection volume and a variety of detection systems have facilitated acceptance of this technology. Since different drug metabolite enantiomers are formed in many metabolic pathways, the other indispensable advantage of CE over HPLC is the possibility of chiral separation without the need of special expensive columns. Recent advances in automated systems have made CE even more popular. The focus of this paper is to review recent studies and advances (mainly from 2000) of drug metabolism by using CE. The review is divided into two parts: (i) principles of CE separation of drugs and their metabolites and (ii) application of CE in drug metabolism studies. The first part introduces sample preparation, separation and detection modes involved in CE drug metabolism studies. To provide a deeper insight into the achievements, distinction between drug metabolism analysis in vivo and in vitro is made in the second part. Reported methods are discussed and summarized.
ER -
ZHANG, Jie, Jiří KONEČNÝ, Zdeněk GLATZ, Jos HOOGMARTENS a Ann VAN SCHEPDAEL. Review: Application of capillary electrophoresis in drug metabolism studies. \textit{Current Analytical Chemistry}. USA: BENTHAM SCIENCE PUBL LTD, 2007, roč.~3, č.~3, s.~197-217. ISSN~1573-4110.
|
